Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women

Gomez-Arango, Luisa F., Barrett, Helen L, McIntyre, H. David, Callaway, Leonie K., Morrison, Mark, Nitert, Marloes Dekker, SPRING Trial Group, Kang, Alicia, Shanahan, Erin, Fukuma, Naoki and Angel, Nicola (2016) Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women. Diabetes, 65 8: 2214-2223. doi:10.2337/db16-0278


Author Gomez-Arango, Luisa F.
Barrett, Helen L
McIntyre, H. David
Callaway, Leonie K.
Morrison, Mark
Nitert, Marloes Dekker
SPRING Trial Group
Kang, Alicia
Shanahan, Erin
Fukuma, Naoki
Angel, Nicola
Title Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women
Journal name Diabetes   Check publisher's open access policy
ISSN 0012-1797
1939-327X
Publication date 2016-10-01
Year available 2016
Sub-type Article (original research)
DOI 10.2337/db16-0278
Open Access Status Not yet assessed
Volume 65
Issue 8
Start page 2214
End page 2223
Total pages 10
Place of publication Arlington, VA, United States
Publisher American Diabetes Association
Language eng
Abstract Overweight and obese women are at a higher risk for gestational diabetes mellitus. The gut microbiome could modulate metabolic health and may affect insulin resistance and lipid metabolism. The aim of this study was to reveal relationships between gut microbiome composition and circulating metabolic hormones in overweight and obese pregnant women at 16 weeks' gestation. Fecal microbiota profiles from overweight (n = 29) and obese (n = 41) pregnant women were assessed by 16S rRNA sequencing. Fasting metabolic hormone (insulin, C-peptide, glucagon, incretin, and adipokine) concentrations were measured using multiplex ELISA. Metabolic hormone levels as well as microbiome profiles differed between overweight and obese women. Furthermore, changes in some metabolic hormone levels were correlated with alterations in the relative abundance of specific microbes. Adipokine levels were strongly correlated with Ruminococcaceae and Lachnospiraceae, which are dominant families in energy metabolism. Insulin was positively correlated with the genus Collinsella. Gastrointestinal polypeptide was positively correlated with the genus Coprococcus but negatively with family Ruminococcaceae. This study shows novel relationships between gut microbiome composition and the metabolic hormonal environment in overweight and obese pregnant women at 16 weeks' gestation. These results suggest that manipulation of the gut microbiome composition may influence pregnancy metabolism.
Keyword Chain Fatty-Acids
Intestinal Microbiota
Body-Weight
Leptin
Mice
Associations
Inflammation
Adiposity
Profiles
Ecology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1028575
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
UQ Centre for Clinical Research Publications
HERDC Pre-Audit
School of Medicine Publications
 
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Created: Sat, 04 Nov 2017, 20:00:47 EST by Shelley Wilkinson on behalf of School of Pharmacy