Assessing tumor-infiltrating lymphocytes in solid tumors: A practical review for pathologists and proposal for a standardized method from the international immuno-oncology biomarkers working group: Part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors

Hendry, Shona, Salgado, Roberto, Gevaert, Thomas, Russell, Prudence A., John, Tom, Thapa, Bibhusal, Christie, Michael, Van De Vijver, Koen, Estrada, M. V., Gonzalez-Ericsson, Paula I., Sanders, Melinda, Solomon, Benjamin, Solinas, Cinzia, Van Den Eynden, Gert G.G.M., Allory, Yves, Preusser, Matthias, Hainfellner, Johannes, Pruneri, Giancarlo, Vingiani, Andrea, Demaria, Sandra, Symmans, Fraser, Nuciforo, Paolo, Comerma, Laura, Thompson, E. A., Lakhani, Sunil, Kim, Seong-Rim, Schnitt, Stuart, Colpaert, Cecile, Sotiriou, Christos, Scherer, Stefan J., Ignatiadis, Michail, Badve, Sunil, Pierce, Robert H., Viale, Giuseppe, Sirtaine, Nicolas, Penault-Llorca, Frederique, Sugie, Tomohagu, Fineberg, Susan, Paik, Soonmyung, Srinivasan, Ashok, Richardson, Andrea, Wang, Yihong, Chmielik, Ewa, Brock, Jane, Johnson, Douglas B., Balko, Justin, Wienert, Stephan, Bossuyt, Veerle, Michiels, Stefan, Ternes, Nils, Burchardi, Nicole, Luen, Stephen J., Savas, Peter, Klauschen, Frederick, Watson, Peter H., Nelson, Brad H., Criscitiello, Carmen, O'Toole, Sandra, Larsimont, Denis, De Wind, Roland, Curigliano, Giuseppe, André, Fabrice, Lacroix-Triki, Magali, Van De Vijver, Mark, Rojo, Federico, Floris, Giuseppe, Bedri, Shahinaz, Sparano, Joseph, Rimm, David, Nielsen, Torsten, Kos, Zuzana, Hewitt, Stephen, Singh, Baljit, Farshid, Gelareh, Loibl, Sibylle, Allison, Kimberly H., Tung, Nadine, Adams, Sylvia, Willard-Gallo, Karen, Horlings, Hugo M., Gandhi, Leena, Moreira, Andre, Hirsch, Fred, Dieci, Maria V., Urbanowicz, Maria, Brcic, Iva, Korski, Konstanty, Gaire, Fabien, Koeppen, Hartmut, Lo, Amy, Giltnane, Jennifer, Rebelatto, Marlon C., Steele, Keith E., Zha, Jiping, Emancipator, Kenneth, Juco, Jonathan W., Denkert, Carsten, Reis-Filho, Jorge, Loi, Sherene and Fox, Stephen B. (2017) Assessing tumor-infiltrating lymphocytes in solid tumors: A practical review for pathologists and proposal for a standardized method from the international immuno-oncology biomarkers working group: Part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors. Advances in Anatomic Pathology, 24 6: 311-335. doi:10.1097/PAP.0000000000000161


Author Hendry, Shona
Salgado, Roberto
Gevaert, Thomas
Russell, Prudence A.
John, Tom
Thapa, Bibhusal
Christie, Michael
Van De Vijver, Koen
Estrada, M. V.
Gonzalez-Ericsson, Paula I.
Sanders, Melinda
Solomon, Benjamin
Solinas, Cinzia
Van Den Eynden, Gert G.G.M.
Allory, Yves
Preusser, Matthias
Hainfellner, Johannes
Pruneri, Giancarlo
Vingiani, Andrea
Demaria, Sandra
Symmans, Fraser
Nuciforo, Paolo
Comerma, Laura
Thompson, E. A.
Lakhani, Sunil
Kim, Seong-Rim
Schnitt, Stuart
Colpaert, Cecile
Sotiriou, Christos
Scherer, Stefan J.
Ignatiadis, Michail
Badve, Sunil
Pierce, Robert H.
Viale, Giuseppe
Sirtaine, Nicolas
Penault-Llorca, Frederique
Sugie, Tomohagu
Fineberg, Susan
Paik, Soonmyung
Srinivasan, Ashok
Richardson, Andrea
Wang, Yihong
Chmielik, Ewa
Brock, Jane
Johnson, Douglas B.
Balko, Justin
Wienert, Stephan
Bossuyt, Veerle
Michiels, Stefan
Ternes, Nils
Burchardi, Nicole
Luen, Stephen J.
Savas, Peter
Klauschen, Frederick
Watson, Peter H.
Nelson, Brad H.
Criscitiello, Carmen
O'Toole, Sandra
Larsimont, Denis
De Wind, Roland
Curigliano, Giuseppe
André, Fabrice
Lacroix-Triki, Magali
Van De Vijver, Mark
Rojo, Federico
Floris, Giuseppe
Bedri, Shahinaz
Sparano, Joseph
Rimm, David
Nielsen, Torsten
Kos, Zuzana
Hewitt, Stephen
Singh, Baljit
Farshid, Gelareh
Loibl, Sibylle
Allison, Kimberly H.
Tung, Nadine
Adams, Sylvia
Willard-Gallo, Karen
Horlings, Hugo M.
Gandhi, Leena
Moreira, Andre
Hirsch, Fred
Dieci, Maria V.
Urbanowicz, Maria
Brcic, Iva
Korski, Konstanty
Gaire, Fabien
Koeppen, Hartmut
Lo, Amy
Giltnane, Jennifer
Rebelatto, Marlon C.
Steele, Keith E.
Zha, Jiping
Emancipator, Kenneth
Juco, Jonathan W.
Denkert, Carsten
Reis-Filho, Jorge
Loi, Sherene
Fox, Stephen B.
Title Assessing tumor-infiltrating lymphocytes in solid tumors: A practical review for pathologists and proposal for a standardized method from the international immuno-oncology biomarkers working group: Part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors
Journal name Advances in Anatomic Pathology   Check publisher's open access policy
ISSN 1533-4031
1072-4109
Publication date 2017-01-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/PAP.0000000000000161
Open Access Status PMC
Volume 24
Issue 6
Start page 311
End page 335
Total pages 25
Place of publication Philadelphia, PA ., United States
Publisher Lippincott Williams and Wilkins
Language eng
Subject 2702 Anatomy
2734 Pathology and Forensic Medicine
Abstract Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
Keyword Biomarkers
Cancer
Immunotherapy
Lymphocytes
Pathology
Tumor-infiltrating
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID K23 CA204726
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
School of Medicine Publications
 
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Created: Fri, 03 Nov 2017, 11:20:59 EST