MnAl layered double hydroxide nanoparticles as a dual-functional platform for magnetic resonance imaging and siRNA delivery

Zuo, Huali, Chen, Weiyu, Li, Bei, Xu, Kewei, Cooper, Helen, Gu, Zi and Xu, Zhi Ping (2017) MnAl layered double hydroxide nanoparticles as a dual-functional platform for magnetic resonance imaging and siRNA delivery. Chemistry - A European Journal, 23 57: 14299-14306. doi:10.1002/chem.201702835


Author Zuo, Huali
Chen, Weiyu
Li, Bei
Xu, Kewei
Cooper, Helen
Gu, Zi
Xu, Zhi Ping
Title MnAl layered double hydroxide nanoparticles as a dual-functional platform for magnetic resonance imaging and siRNA delivery
Journal name Chemistry - A European Journal   Check publisher's open access policy
ISSN 1521-3765
0947-6539
Publication date 2017-09-14
Year available 2017
Sub-type Article (original research)
DOI 10.1002/chem.201702835
Open Access Status Not yet assessed
Volume 23
Issue 57
Start page 14299
End page 14306
Total pages 8
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Subject 1600 Chemistry
Abstract Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this work, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDH) were examined as an effective anticancer drug/gene delivery system and for T-weighted magnetic resonance imaging (MRI) in brain cancer theranostics. Such Mn-LDH have been shown to accommodate dsDNA/siRNAs and efficiently deliver them to Neuro-2a cells (N2a). Mn-LDH have also shown high biocompatibility with low cytotoxicity. Importantly, the cell-death siRNA (CD-siRNA) delivered with Mn-LDH more efficiently kills brain cancer cells than the free CD-siRNA. Moreover, Mn-LDH can act as excellent contrast agents for MRI, with an r value of 4.47 mm s, which is even higher than that of commercial contrast agents based on Gd complexes (r=3.4 mm s). Altogether, the high delivery efficacy and MRI contrast capability make dual-functional Mn-LDH potential bimodal agents for simultaneous cancer diagnosis and therapy.
Keyword Drug delivery
Layered compounds
Nanoparticles
Nuclear magnetic resonance
Theranostics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1073591
FT120100813
Institutional Status UQ

 
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Created: Fri, 03 Nov 2017, 09:10:56 EST