Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

Alif, Sheikh M., Dharmage, Shyamali C., Benke, Geza, Dennekamp, Martine, Burgess, John A., Perret, Jennifer L., Lodge, Caroline J., Morrison, Stephen, Johns, David Peter, Giles, Graham G., Gurrin, Lyle C., Thomas, Paul S., Hopper, John Llewelyn, Wood-Baker, Richard, Thompson, Bruce R., Feather, Iain H., Vermeulen, Roel, Kromhout, Hans, Walters, E Haydn, Abramson, Michael J. and Matheson, Melanie Claire (2017) Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age. Thorax, 72 11: 990-997. doi:10.1136/thoraxjnl-2016-209665


Author Alif, Sheikh M.
Dharmage, Shyamali C.
Benke, Geza
Dennekamp, Martine
Burgess, John A.
Perret, Jennifer L.
Lodge, Caroline J.
Morrison, Stephen
Johns, David Peter
Giles, Graham G.
Gurrin, Lyle C.
Thomas, Paul S.
Hopper, John Llewelyn
Wood-Baker, Richard
Thompson, Bruce R.
Feather, Iain H.
Vermeulen, Roel
Kromhout, Hans
Walters, E Haydn
Abramson, Michael J.
Matheson, Melanie Claire
Title Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age
Journal name Thorax   Check publisher's open access policy
ISSN 1468-3296
0040-6376
Publication date 2017-11-01
Year available 2017
Sub-type Article (original research)
DOI 10.1136/thoraxjnl-2016-209665
Open Access Status Not yet assessed
Volume 72
Issue 11
Start page 990
End page 997
Total pages 8
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
Abstract Rationale Population-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occupational exposures are a modifiable risk factor for COPD. Objectives To investigate the associations between occupational exposures and fixed airflow obstruction using postbronchodilator spirometry. Methods One thousand three hundred and thirty-five participants were included from 2002 to 2008 follow-up of the Tasmanian Longitudinal Health Study (TAHS). Spirometry was performed and lifetime work history calendars were used to collect occupational history. ALOHA plus Job Exposure Matrix was used to assign occupational exposure, and defined as ever exposed and cumulative exposure unit (EU)-years. Fixed airflow obstruction was defined by postbronchodilator FEV 1/FVC <0.7 and the lower limit of normal (LLN). Multinomial logistic regressions were used to investigate potential associations while controlling for possible confounders. Results Ever exposure to biological dust (relative risk (RR)=1.58, 95% CI 1.01 to 2.48), pesticides (RR=1.74,95% CI 1.00 to 3.07) and herbicides (RR=2.09,95% CI 1.18 to 3.70) were associated with fixed airflow obstruction. Cumulative EU-years to all pesticides (RR=1.11,95% CI 1.00 to 1.25) and herbicides (RR=1.15,95% CI 1.00 to 1.32) were also associated with fixed airflow obstruction. In addition, all pesticides exposure was consistently associated with chronic bronchitis and symptoms that are consistent with airflow obstruction. Ever exposure to mineral dust, gases/fumes and vapours, gases, dust or fumes were only associated with fixed airflow obstruction in non-asthmatics only. Conclusions Pesticides and herbicides exposures were associated with fixed airflow obstruction and chronic bronchitis. Biological dust exposure was also associated with fixed airflow obstruction in non-asthmatics. Minimising occupational exposure to these agents may help to reduce the burden of COPD.
Keyword Airflow obstruction
ALOHA JEM
Chronic obstructive pulmonary disease
Job exposure matrix
Occupational exposure
Pesticide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Faculty of Medicine
 
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Created: Fri, 03 Nov 2017, 09:06:43 EST