Birth-weight centiles and the risk of serious adverse neonatal outcomes at term

Yu, Joanna, Flatley, Christopher, Greer, Ristan M. and Kumar, Sailesh (2017) Birth-weight centiles and the risk of serious adverse neonatal outcomes at term. Journal of Perinatal Medicine, . doi:10.1515/jpm-2017-0176

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Author Yu, Joanna
Flatley, Christopher
Greer, Ristan M.
Kumar, Sailesh
Title Birth-weight centiles and the risk of serious adverse neonatal outcomes at term
Journal name Journal of Perinatal Medicine   Check publisher's open access policy
ISSN 0300-5577
Publication date 2017-12-19
Sub-type Article (original research)
DOI 10.1515/jpm-2017-0176
Open Access Status File (Publisher version)
Total pages 9
Place of publication Berlin, Germany
Publisher Walter de Gruyter
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
2729 Obstetrics and Gynaecology
Abstract Birth-weight is an important determinant of perinatal outcome with low birth-weight being a particular risk factor for adverse consequences. To investigate the impact of neonatal sex, mode of birth and gestational age at birth according to birth-weight centile on serious adverse neonatal outcomes in singleton term pregnancies. This was a retrospective cohort study of singleton term births at the Mater Mother's Hospital, Brisbane, Australia. Serious adverse neonatal outcome was defined as a composite of severe acidosis at birth (pH ≤7.0 and/or lactate ≥6 mmol/L and/or base excess ≤-12 mmol/L), Apgar <3 at 5 min, neonatal intensive-care unit admission and antepartum or neonatal death. The main exposure variable was birth-weight centile. Of the 69,210 babies in our study, the overall proportion of serious adverse neonatal outcomes was 9.1% (6327/69,210). Overall, neonates in the <3 birth-weight centile category had the highest adjusted odds ratio (OR) for serious adverse neonatal outcomes [OR 3.53, 95% confidence interval (CI) 3.06-4.07], whilst those in the ≥97 centile group also had elevated odds (OR 1.51, 95% CI 1.30-1.75). Regardless of birth modality, smaller babies in the <3 centile group had the highest adjusted OR and predicted probability for serious adverse neonatal outcomes. When stratified by sex, male babies consistently demonstrated a higher predicted probability of serious adverse neonatal outcomes across all birth-weight centiles. The adjusted odds, when stratified by gestational age at birth, were the highest from 37+0 to 38+6 weeks in the <3 centile group (OR 5.97, 95% CI 4.60-7.75). Low and high birth-weights are risk factors for serious adverse neonatal outcomes. The adjusted OR appears to be greatest for babies in the <3 birth-weight centile group, although an elevated risk was also found in babies within the ≥97 centile category.
Keyword Birth-weight
Gestational age
Mode of birth
Serious adverse neonatal outcomes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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Created: Wed, 01 Nov 2017, 10:30:52 EST by Johanna Barclay on behalf of Mater Research Institute-UQ