Evidence-based source modeling of nociceptive cortical responses: a direct comparison of scalp and intracranial activity in humans

Bradley, Claire, Bastuji, Helene and Garcia-Larrea, Luis (2017) Evidence-based source modeling of nociceptive cortical responses: a direct comparison of scalp and intracranial activity in humans. Human Brain Mapping, 38 12: 6083-6095. doi:10.1002/hbm.23812


Author Bradley, Claire
Bastuji, Helene
Garcia-Larrea, Luis
Title Evidence-based source modeling of nociceptive cortical responses: a direct comparison of scalp and intracranial activity in humans
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
1097-0193
Publication date 2017-09-18
Sub-type Article (original research)
DOI 10.1002/hbm.23812
Open Access Status Not yet assessed
Volume 38
Issue 12
Start page 6083
End page 6095
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Source modeling of EEG traditionally relies on interplay between physiological hypotheses and mathematical estimates. We propose to optimize the process by using evidence gathered from brain imaging and intracortical recordings.

We recorded laser-evoked potentials in 18 healthy participants, using high-density EEG. Brain sources were modeled during the first second poststimulus, constraining their initial position to regions where nociceptive-related activity has been ascertained by intracranial EEG. These comprised the two posterior operculo-insular regions, primary sensorimotor, posterior parietal, anterior cingulate/supplementary motor (ACC/SMA), bilateral frontal/anterior insular, and posterior cingulate (PCC) cortices.

The model yielded an average goodness of fit of 91% for individual and 95.8% for grand-average data. When compared with intracranial recordings from 27 human subjects, no significant difference in peak latencies was observed between modeled and intracranial data for 5 of the 6 assessable regions. Morphological match was excellent for operculo-insular, frontal, ACC/SMA and PCC regions (cross-correlation > 0.7) and fair for sensori-motor and posterior parietal cortex (c-c ∼ 0.5).

Multiple overlapping activities evoked by nociceptive input can be disentangled from high-density scalp EEG guided by intracranial data. Modeled sources accurately described the timing and morphology of most activities recorded with intracranial electrodes, including those coinciding with the emergence of stimulus awareness. Hum Brain Mapp 38:6083-6095, 2017. © 2017 Wiley Periodicals, Inc.
Keyword insula
laser-evoked potentials
pain
sEEG
source modeling
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: eSpace Followup
Queensland Brain Institute Publications
 
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Created: Mon, 30 Oct 2017, 09:47:19 EST by Claire Bradley on behalf of Queensland Brain Institute