The THINC-integrated tool (THINC-it) screening assessment for cognitive dysfunction: Validation in patients with major depressive disorder

McIntyre, Roger S., Best, Michael W., Bowie, Christopher R., Carmona, Nicole E., Cha, Danielle S., Lee, Yena, Subramaniapillai, Mehala, Mansur, Rodrigo B., Barry, Harry, Baune, Bemhard T., Culpepper, Larry, Fossati, Philippe, Greer, Tracy L., Harmer, Catherine, Klag, Esther, Lam, Raymond W., Wittchen, Hans-Ulrich and Harrison, John (2017) The THINC-integrated tool (THINC-it) screening assessment for cognitive dysfunction: Validation in patients with major depressive disorder. Journal of Clinical Psychiatry, 78 7: 873-881. doi:10.4088/JCP.16m11329

Author McIntyre, Roger S.
Best, Michael W.
Bowie, Christopher R.
Carmona, Nicole E.
Cha, Danielle S.
Lee, Yena
Subramaniapillai, Mehala
Mansur, Rodrigo B.
Barry, Harry
Baune, Bemhard T.
Culpepper, Larry
Fossati, Philippe
Greer, Tracy L.
Harmer, Catherine
Klag, Esther
Lam, Raymond W.
Wittchen, Hans-Ulrich
Harrison, John
Title The THINC-integrated tool (THINC-it) screening assessment for cognitive dysfunction: Validation in patients with major depressive disorder
Journal name Journal of Clinical Psychiatry   Check publisher's open access policy
ISSN 0160-6689
Publication date 2017-07-01
Year available 2017
Sub-type Article (original research)
DOI 10.4088/JCP.16m11329
Open Access Status Not yet assessed
Volume 78
Issue 7
Start page 873
End page 881
Total pages 9
Place of publication Memphis, TN, United States
Publisher Physicians Postgraduate Press
Language eng
Subject 2738 Psychiatry and Mental health
Abstract Objective: To validate the THINC-integrated tool (THINC-it).a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). Methods: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test.Part B, and the Perceived Deficits Questionnaire for Depression.5-item (PDQ-5-D). Results: The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P <.001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received. Conclusions: The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Danielle Soh-Young is a coursework student

Document type: Journal Article
Sub-type: Article (original research)
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Faculty of Medicine
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