The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

Yang, Daryl C., Dobson, James, Cochran, Chip, Dashevsky, Daniel, Arbuckle, Kevin, Benard, Melisa, Boyer, Leslie, Alagon, Alejandro, Hendrikx, Iwan, Hodgson, Wayne C. and Fry, Bryan G. (2017) The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom. Neurotoxicity Research, 32 3: 487-495. doi:10.1007/s12640-017-9771-4


Author Yang, Daryl C.
Dobson, James
Cochran, Chip
Dashevsky, Daniel
Arbuckle, Kevin
Benard, Melisa
Boyer, Leslie
Alagon, Alejandro
Hendrikx, Iwan
Hodgson, Wayne C.
Fry, Bryan G.
Title The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom
Journal name Neurotoxicity Research   Check publisher's open access policy
ISSN 14763524 10298428
Publication date 2017-10-01
Sub-type Article (original research)
DOI 10.1007/s12640-017-9771-4
Open Access Status Not yet assessed
Volume 32
Issue 3
Start page 487
End page 495
Total pages 9
Publisher Springer New York LLC
Language eng
Abstract Coral snake envenomations are well characterized to be lethally neurotoxic. Despite this, few multispecies, neurotoxicity and antivenom efficacy comparisons have been undertaken and only for the Micrurus genus; Micruroides has remained entirely uninvestigated. As the USA's supplier of antivenom has currently stopped production, alternative sources need to be explored. The Mexican manufacturer Bioclon uses species genetically related to USA species, thus we investigated the efficacy against Micrurus fulvius (eastern coral snake), the main species responsible for lethal envenomations in the USA as well as additional species from the Americas. The use of Coralmyn® coral snake antivenom was effective in neutralizing the neurotoxic effects exhibited by the venom of M. fulvius but was ineffective against the venoms of Micrurus tener, Micrurus spixii, Micrurus pyrrhocryptus, and Micruroides euryxanthus. Our results suggest that the Mexican antivenom may be clinically useful for the treatment of M. fulvius in the USA but may be of only limited efficacy against the other species studied.
Keyword Antivenom
Coral snake
Micruroides
Micrurus
Neurotoxicity
Venom
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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Created: Mon, 25 Sep 2017, 01:00:46 EST by Web Cron