Interaction effect between 5-HTTLPR and HTR1A rs6295 polymorphisms on the frontoparietal network

Long, Haixia, Liu, Bing, Wang, Chao, Zhang, Xiaolong, Li, Jin, Yu, Chunshui and Jiang, Tianzi (2017) Interaction effect between 5-HTTLPR and HTR1A rs6295 polymorphisms on the frontoparietal network. Neuroscience, 32 239-247. doi:10.1016/j.neuroscience.2017.08.003


Author Long, Haixia
Liu, Bing
Wang, Chao
Zhang, Xiaolong
Li, Jin
Yu, Chunshui
Jiang, Tianzi
Title Interaction effect between 5-HTTLPR and HTR1A rs6295 polymorphisms on the frontoparietal network
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
1873-7544
Publication date 2017-08-06
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.neuroscience.2017.08.003
Open Access Status Not yet assessed
Volume 32
Start page 239
End page 247
Total pages 9
Place of publication Kidlington, Oxford United Kingdom
Publisher Pergamon Press
Language eng
Subject 2800 Neuroscience
Abstract Previous studies have shown a close relationship between the serotonin system and working memory (WM), but the neural mechanism for the role of the serotonin system on the WM is unclear. The frontoparietal network is involved in WM and is associated with the serotonin system. Therefore, this study investigated the interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the frontoparietal network obtained from the independent component analysis in a large, young Chinese sample population. The current study found a significant interaction effect of 5-HTTLPR and rs6295 on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Moreover, the mean connectivity in the right inferior parietal lobule was positively correlated with WM performance. These brain network analysis findings could provide a new perspective on the neural mechanisms of gene-gene interactions and on individual differences in cognitive functions. (C) 2017 Published by Elsevier Ltd on behalf of IBRO.
Keyword Working-Memory Performance
Major Depressive Disorder
Default Mode Network
Knock-Out Mice
Serotonin Transporter
Prefrontal Cortex
5-Ht1A Receptor
Human Brain
Genetic Polymorphisms
Chinese Population
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Thu, 21 Sep 2017, 13:46:58 EST by Kirstie Asmussen on behalf of Queensland Brain Institute