Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

Chen, Guo-Bo, Lee, Sang Hong, Montgomery, Grant W., Wray, Naomi R., Visscher, Peter M., Gearry, Richard B., Lawrance, Ian C., Andrews, Jane M., Bampton, Peter, Mahy, Gillian, Bell, Sally, Walsh, Alissa, Connor, Susan, Sparrow, Miles, Bowdler, Lisa M., Simms, Lisa A., Krishnaprasad, Krupa, Radford-Smith, Graham L. and Moser, Gerhard (2017) Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method. BMC Medical Genetics, 18 1: 94-94. doi:10.1186/s12881-017-0451-2


Author Chen, Guo-Bo
Lee, Sang Hong
Montgomery, Grant W.
Wray, Naomi R.
Visscher, Peter M.
Gearry, Richard B.
Lawrance, Ian C.
Andrews, Jane M.
Bampton, Peter
Mahy, Gillian
Bell, Sally
Walsh, Alissa
Connor, Susan
Sparrow, Miles
Bowdler, Lisa M.
Simms, Lisa A.
Krishnaprasad, Krupa
Radford-Smith, Graham L.
Moser, Gerhard
Title Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method
Journal name BMC Medical Genetics   Check publisher's open access policy
ISSN 1471-2350
Publication date 2017-08-29
Year available 2017
Sub-type Article (original research)
DOI 10.1186/s12881-017-0451-2
Open Access Status DOI
Volume 18
Issue 1
Start page 94
End page 94
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Predicting risk of disease from genotypes is being increasingly proposed for a variety of diagnostic and prognostic purposes. Genome-wide association studies (GWAS) have identified a large number of genome-wide significant susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC), two subtypes of inflammatory bowel disease (IBD). Recent studies have demonstrated that including only loci that are significantly associated with disease in the prediction model has low predictive power and that power can substantially be improved using a polygenic approach.
Keyword Case-control study
Complex trait
Crohn's disease
Inflammatory bowel disease
Risk score
SNP array
Ulcerative colitis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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