Concepts, estimation and interpretation of SNP-based heritability

Yang, Jian, Zeng, Jian, Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2017) Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49 9: 1304-1310. doi:10.1038/ng.3941

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Author Yang, Jian
Zeng, Jian
Goddard, Michael E.
Wray, Naomi R.
Visscher, Peter M.
Title Concepts, estimation and interpretation of SNP-based heritability
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2017-09-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ng.3941
Open Access Status File (Author Post-print)
Volume 49
Issue 9
Start page 1304
End page 1310
Total pages 7
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Abstract Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants. Estimation of h(2) previously relied on closely related individuals, but recent developments allow estimation of the variance explained by all SNPs used in a genome-wide association study (GWAS) in conventionally unrelated individuals, that is, the SNP-based heritability (). In this Perspective, we discuss recently developed methods to estimate for a complex trait (and genetic correlation between traits) using individual-level or summary GWAS data. We discuss issues that could influence the accuracy of , definitions, assumptions and interpretations of the models, and pitfalls of misusing the methods and misinterpreting the models and results.
Keyword Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Institute for Molecular Bioscience - Publications
 
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