Molecular introduction to head and neck cancer (HNSCC) carcinogenesis

Chin, D, Boyle, GM, Theile, DR, Parsons, PG and Coman, WB (2004) Molecular introduction to head and neck cancer (HNSCC) carcinogenesis. British Journal of Plastic Surgery, 57 7: 595-602. doi:10.1016/j.bjps.2004.06.010


Author Chin, D
Boyle, GM
Theile, DR
Parsons, PG
Coman, WB
Title Molecular introduction to head and neck cancer (HNSCC) carcinogenesis
Journal name British Journal of Plastic Surgery   Check publisher's open access policy
ISSN 0007-1226
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.bjps.2004.06.010
Open Access Status Not yet assessed
Volume 57
Issue 7
Start page 595
End page 602
Total pages 8
Editor N. Parkhouse
Place of publication Edinburgh, U.K.
Publisher Churchill Livinstone
Language eng
Subject C1
320307 Medical Biochemistry - Other
730108 Cancer and related disorders
Abstract Of all human cancers, HNSCC is the most distressing affecting pain, disfigurement, speech and the basic survival functions of breathing and swallowing. Mortality rates have not significantly changed in the last 40 years despite advances in radiotherapy and surgical treatment. Molecular markers are currently being identified that can determine prognosis preoperatively by routine tumour biopsy Leading to improved management of HNSCC patients. The approach could help decide which early stage patient should have adjuvant neck dissection and radiotherapy, and whether Later stage patients with operable lesions would benefit from resection and reconstructive surgery or adopt a conservative approach to patients with poor prognosis regardless of treatment. In the future, understanding these basic genetic changes in HNSCC would be important for the management of HNSCC. (C) 2004 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.
Keyword Surgery
Tumorigenesis
Oncogenes
Angiogenesis
Hnscc
Molecular Markers
Squamous-cell Carcinoma
Endothelial Growth-factor
Tumor-suppressor Gene
Chromosome 11q13 Amplification
P53 Protein Accumulation
Cyclin D1
Oncogene Amplification
In-vivo
Poor-prognosis
Breast-cancer
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 13:05:45 EST