The circadian response of intrinsically photosensitive retinal ganglion cells

Zele, Andrew J., Feigl, Beatrix, Smith, Simon S. and Markwell, Emma L. (2011) The circadian response of intrinsically photosensitive retinal ganglion cells. PLoS One, 6 3: . doi:10.1371/journal.pone.0017860


Author Zele, Andrew J.
Feigl, Beatrix
Smith, Simon S.
Markwell, Emma L.
Title The circadian response of intrinsically photosensitive retinal ganglion cells
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-03-14
Sub-type Article (original research)
DOI 10.1371/journal.pone.0017860
Open Access Status DOI
Volume 6
Issue 3
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Abstract Intrinsically photosensitive retinal ganglion cells (ipRGC) signal environmental light level to the central circadian clock and contribute to the pupil light reflex. It is unknown if ipRGC activity is subject to extrinsic (central) or intrinsic (retinal) network-mediated circadian modulation during light entrainment and phase shifting. Eleven younger persons (18–30 years) with no ophthalmological, medical or sleep disorders participated. The activity of the inner (ipRGC) and outer retina (cone photoreceptors) was assessed hourly using the pupil light reflex during a 24 h period of constant environmental illumination (10 lux). Exogenous circadian cues of activity, sleep, posture, caffeine, ambient temperature, caloric intake and ambient illumination were controlled. Dim-light melatonin onset (DLMO) was determined from salivary melatonin assay at hourly intervals, and participant melatonin onset values were set to 14 h to adjust clock time to circadian time. Here we demonstrate in humans that the ipRGC controlled post-illumination pupil response has a circadian rhythm independent of external light cues. This circadian variation precedes melatonin onset and the minimum ipRGC driven pupil response occurs post melatonin onset. Outer retinal photoreceptor contributions to the inner retinal ipRGC driven post-illumination pupil response also show circadian variation whereas direct outer retinal cone inputs to the pupil light reflex do not, indicating that intrinsically photosensitive (melanopsin) retinal ganglion cells mediate this circadian variation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Social Science Research - Publications
 
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