Physical activity and survival among long-term cancer survivor and non-cancer cohorts

Gunnell, Anthony S., Joyce, Sarah, Tomlin, Stephania, Taaffe, Dennis R., Cormie, Prue, Newton, Robert U., Joseph, David, Spry, Nigel, Einarsdottir, Kristjana and Galvao, Daniel A. (2017) Physical activity and survival among long-term cancer survivor and non-cancer cohorts. Frontiers in Public Health, 5 . doi:10.3389/fpubh.2017.00019

Author Gunnell, Anthony S.
Joyce, Sarah
Tomlin, Stephania
Taaffe, Dennis R.
Cormie, Prue
Newton, Robert U.
Joseph, David
Spry, Nigel
Einarsdottir, Kristjana
Galvao, Daniel A.
Title Physical activity and survival among long-term cancer survivor and non-cancer cohorts
Journal name Frontiers in Public Health   Check publisher's open access policy
ISSN 2296-2565
Publication date 2017-02-14
Sub-type Article (original research)
DOI 10.3389/fpubh.2017.00019
Open Access Status DOI
Volume 5
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract Evidence suggests physical activity improves prognosis following cancer diagnosis; however, evidence regarding prognosis in long-term survivors of cancer is scarce. We assessed physical activity in 1,589 cancer survivors at an average 8.8 years following their initial diagnosis and calculated their future mortality risk following physical activity assessment. We also selected a cancer-free cohort of 3,145 age, sex, and survey year group-matched cancer-free individuals from the same source population for comparison purposes. Risks for cancer-specific mortality and all-cause mortality in relation to physical activity levels were estimated using Cox regression proportional hazard regression analyses within the cancer and non-cancer cohorts. Physical activity levels of 360+ min per week were inversely associated with cancer-specific mortality in long-term cancer survivors [hazard ratios (HR) = 0.30 (95% confidence intervals (CI) 0.13–0.70)] and participants without prior cancer [HR = 0.16 (95% CI 0.05–0.56)] compared with no reported physical activity. Physical activity levels of 150–359 and 360+ min were inversely associated with all-cause mortality in long-term cancer survivors [150–359 min; HR = 0.55 (95% CI 0.31–0.97), 360+ min; HR = 0.41 (95% CI 0.21–0.79)] and those without prior cancer [150–359 min; HR = 0.52 (95% CI 0.32–0.86), 360+ min; HR = 0.50 (95% CI 0.29–0.88)]. These results suggest that meeting exercise guidelines of 150 min of physical activity per week were associated with reduced all-cause mortality in both long-term cancer surviving and cancer-free cohorts. Exceeding exercise oncology guidelines (360+ min per week) may provide additional protection in terms of cancer-specific death.
Keyword Physical activity
Cohort study
Colorectal cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
School of Human Movement and Nutrition Sciences Publications
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