Identification of candidate genes for devil facial tumour disease tumourigenesis

Taylor, Robyn L., Zhang, Yiru, Schoning, Jennifer P. and Deakin, Janine E. (2017) Identification of candidate genes for devil facial tumour disease tumourigenesis. Scientific Reports, 7 1: . doi:10.1038/s41598-017-08908-9

Author Taylor, Robyn L.
Zhang, Yiru
Schoning, Jennifer P.
Deakin, Janine E.
Title Identification of candidate genes for devil facial tumour disease tumourigenesis
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-08-18
Sub-type Article (original research)
DOI 10.1038/s41598-017-08908-9
Open Access Status DOI
Volume 7
Issue 1
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Devil facial tumour (DFT) disease, a transmissible cancer where the infectious agent is the tumour itself, has caused a dramatic decrease in Tasmanian devil numbers in the wild. The purpose of this study was to take a candidate gene/pathway approach to identify potentially perturbed genes or pathways in DFT. A fusion of chromosome 1 and X is posited as the initial event leading to the development of DFT, with the rearranged chromosome 1 material now stably maintained as the tumour spreads through the population. This hypothesis makes chromosome 1 a prime chromosome on which to search for mutations involved in tumourigenesis. As DFT1 has a Schwann cell origin, we selected genes commonly implicated in tumour pathways in human nerve cancers, or cancers more generally, to determine whether they were rearranged in DFT1, and mapped them using molecular cytogenetics. Many cancer-related genes were rearranged, such as the region containing the tumour suppressor NF2 and a copy gain for ERBB3, a member of the epidermal growth factor receptor family of receptor tyrosine kinases implicated in proliferation and invasion of tumours in humans. Our mapping results have provided strong candidates not previously detected by sequencing DFT1 genomes.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FT100100426
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
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