Extracellular vesicles from adipose tissue-A potential role in obesity and type 2 diabetes?

Gao, Xuan, Salomon, Carlos and Freeman, Dilys J. (2017) Extracellular vesicles from adipose tissue-A potential role in obesity and type 2 diabetes?. Frontiers in Endocrinology, 8 . doi:10.3389/fendo.2017.00202


Author Gao, Xuan
Salomon, Carlos
Freeman, Dilys J.
Title Extracellular vesicles from adipose tissue-A potential role in obesity and type 2 diabetes?
Journal name Frontiers in Endocrinology   Check publisher's open access policy
ISSN 1664-2392
Publication date 2017-08-18
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fendo.2017.00202
Open Access Status DOI
Volume 8
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract Adipose tissue plays a key role in the development of insulin resistance and its pathological sequelae, such as type 2 diabetes and non-alcoholic fatty liver disease. Dysfunction in the adipose tissue response to storing excess fatty acids as triglyceride can lead to adipose tissue inflammation and spillover of fatty acids from this tissue and accumulation of fatty acids as lipid droplets in ectopic sites, such as liver and muscle. Extracellular vesicles (EVs) are released from adipocytes and have been proposed to be involved in adipocyte/macrophage cross talk and to affect insulin signaling and transforming growth factor β expression in liver cells leading to metabolic disease. Furthermore EV produced by adipose tissue-derived mesenchymal stem cells (ADSC) can promote angiogenesis and cancer cell migration and have neuroprotective and neuroregenerative properties. ADSC EVs have therapeutic potential in vascular and neurodegenerative disease and may also be used to target specific functional miRNAs to cells. Obesity is associated with an increase in adipose-derived EV which may be related to the metabolic complications of obesity. In this review, we discuss our current knowledge of EV produced by adipose tissue and the potential impact of adipose tissue-derived EV on metabolic diseases associated with obesity.
Keyword Adipocytes
Adipose-derived mesenchymal stem cells
Differentiation
Extracellular vesicles
Insulin resistance
Non-alcoholic fatty liver disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article number 202

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
UQ Centre for Clinical Research Publications
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