A genome-wide linkage study in families with major depression and co-morbid unexplained swelling

Anderson, Carl A., Maclean, Alan, Dunnigan, Matthew G., Pelosi, Anthony J., Murray, Valerie, Mckee, Irene, McDonald, George, Burt, David W., Morrice, David R., Muir, Walter J., Visscher, Peter M. and Blackwood, Douglas H. R. (2008) A genome-wide linkage study in families with major depression and co-morbid unexplained swelling. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147 3: 356-362. doi:10.1002/ajmg.b.30615


Author Anderson, Carl A.
Maclean, Alan
Dunnigan, Matthew G.
Pelosi, Anthony J.
Murray, Valerie
Mckee, Irene
McDonald, George
Burt, David W.
Morrice, David R.
Muir, Walter J.
Visscher, Peter M.
Blackwood, Douglas H. R.
Title A genome-wide linkage study in families with major depression and co-morbid unexplained swelling
Journal name American Journal of Medical Genetics Part B-Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 15524841 1552485X
Publication date 2008-04-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/ajmg.b.30615
Open Access Status
Volume 147
Issue 3
Start page 356
End page 362
Total pages 7
Place of publication HOBOKEN
Publisher WILEY-LISS
Language eng
Abstract Major depressive disorder (MDD) is a common heritable condition. The diversity of the phenotype coupled with aetiological and genetic heterogeneity present formidable obstacles in the search for causative genetic loci. Studies of large families with many affected individuals, and the selection of well-defined clinical subgroups of depression, are two ways to reduce this complexity. Unexplained swelling symptoms (USS) are common in women and many patients give a strong personal and family history of depression. Co-morbid depression and swelling symptoms define a useful sub-phenotype for investigating genetic factors in depression. We have completed a genome-wide linkage analysis using 371 microsatellite markers in four families where MDD is co-morbid with USS. Of 47 affected individuals, 28 had both MDD and unexplained swelling, 11 had symptoms of swelling alone, and 8 had MDD alone. Parametric marker-specific analysis identified one suggestive locus, D8S260 (LOD = 2.02) and non-parametric multipoint variance component analysis identified a region on 7p (LOD = 2.10). A 47 cM suggestive linkage region on chromosome 14q (identified by both parametric and non-parametric methods) was identified and investigated further with fine-mapping markers but the evidence for linkage to this region decreased with increased marker information content. (C) 2007 Wiley-Liss, Inc.
Keyword Fluid retention syndrome
Idiopathic oedema
Unipolar depression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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