Heat sensitivity of wMel Wolbachia during Aedes aegypti development

Ulrich, Jill N., Beier, John C., Devine, Gregor J. and Hugo, Leon E. (2016) Heat sensitivity of wMel Wolbachia during Aedes aegypti development. PLoS Neglected Tropical Diseases, 10 7: e0004873. doi:10.1371/journal.pntd.0004873


Author Ulrich, Jill N.
Beier, John C.
Devine, Gregor J.
Hugo, Leon E.
Title Heat sensitivity of wMel Wolbachia during Aedes aegypti development
Formatted title
Heat sensitivity of wMel Wolbachia during Aedes aegypti development
Journal name PLoS Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2727
1935-2735
Publication date 2016-07-26
Sub-type Article (original research)
DOI 10.1371/journal.pntd.0004873
Open Access Status DOI
Volume 10
Issue 7
Start page e0004873
Total pages 16
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Subject 3000 Pharmacology, Toxicology and Pharmaceutics
2739 Public Health, Environmental and Occupational Health
2725 Infectious Diseases
Abstract The wMel strain of Wolbachia bacteria is known to prevent dengue and Zika virus transmission in the mosquito vector Aedes aegypti. Accordingly, the release of wMel-infected A. aegypti in endemic regions has been recommended by the World Health Organization as a potential strategy for controlling dengue and Zika outbreaks. However, the utility of this approach could be limited if high temperatures in the aquatic habitats where A. aegypti develop are detrimental to Wolbachia. We exposed wMel-infected A. aegypti eggs and larvae to fluctuating daily temperatures of 30–40°C for three, five, or seven days during their development. We found that Wolbachia levels in females emerging from heat treatments were significantly lower than in the controls that had developed at 20–30°C. Notably, seven days of high temperatures starting at the egg stage reduced Wolbachia levels in emerging females to less than 0.1% of the wMel control levels. However, after adult females returned to 20–30°C for 4–7 days, they experienced differing degrees of Wolbachia recovery. Our findings suggest that the spread of Wolbachia in wild A. aegypti populations and any consequent protection from dengue and Zika viruses might be limited in ecosystems that experience periods of extreme heat, but Wolbachia levels recover partially after temperatures return to normal.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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Created: Fri, 08 Sep 2017, 15:33:05 EST by Liz Eden on behalf of Qld Alliance for Agriculture and Food Innovation