Effects of transcranial direct current stimulation on neural network structure in young and older adults

Martin, Andrew, Meinzer, Marcus, Lindenberg, Robert, Sieg, Mira M., Nachtigall, Laura and Flöel, Agnes (2017) Effects of transcranial direct current stimulation on neural network structure in young and older adults. Journal of Cognitive Neuroscience, 29 11: 1817-1828. doi:10.1162/jocn_a_01166


Author Martin, Andrew
Meinzer, Marcus
Lindenberg, Robert
Sieg, Mira M.
Nachtigall, Laura
Flöel, Agnes
Title Effects of transcranial direct current stimulation on neural network structure in young and older adults
Journal name Journal of Cognitive Neuroscience   Check publisher's open access policy
ISSN 0898-929X
1530-8898
Publication date 2017-07-14
Year available 2017
Sub-type Article (original research)
DOI 10.1162/jocn_a_01166
Open Access Status Not yet assessed
Volume 29
Issue 11
Start page 1817
End page 1828
Total pages 12
Place of publication Cambridge, MA, United States
Publisher M I T Press
Language eng
Subject 2805 Cognitive Neuroscience
Abstract Transcranial direct current stimulation (tDCS) may be a viable tool to improve motor and cognitive function in advanced age. However, although a number of studies have demonstrated improved cognitive performance in older adults, other studies have failed to show restorative effects. The neural effects of beneficial stimulation response in both age groups is lacking. In the current study, tDCS was administered during simultaneous fMRI in 42 healthy young and older participants. Semantic word generation and motor speech baseline tasks were used to investigate behavioral and neural effects of uni- and bihemispheric motor cortex tDCS in a three-way, crossover, sham tDCS controlled design. Independent components analysis assessed differences in task-related activity between the two age groups and tDCS effects at the network level. We also explored whether laterality of language network organization was effected by tDCS. Behaviorally, both active tDCS conditions significantly improved semantic word retrieval performance in young and older adults and were comparable between groups and stimulation conditions. Network-level tDCS effects were identified in the ventral and dorsal anterior cingulate networks in the combined sample during semantic fluency and motor speech tasks. In addition, a shift toward enhanced left laterality was identified in the older adults for both active stimulation conditions. Thus, tDCS results in common network-level modulations and behavioral improvements for both age groups, with an additional effect of increasing left laterality in older adults.
Keyword Noninvasive Brain-Stimulation
Motor Cortex Stimulation
Semantic Fluency
Aging Brain
Language Lateralization
Cognitive Neuroscience
Poststroke Aphasia
Functional Mri
Frontal-Cortex
Verbal Fluency
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ARC FT120100608
379-8/1
FKZ0315673A
2011-119
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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Created: Thu, 07 Sep 2017, 11:30:41 EST by Andrew Martin on behalf of UQ Centre for Clinical Research