The relationship between partial upper-airway obstruction and inter-breath transition period during sleep

Mann, Dwayne L., Edwards, Bradley A., Joosten, Simon A., Hamilton, Garun S., Landry, Shane, Sands, Scott A., Wilson, Stephen J. and Terrill, Philip I. (2017) The relationship between partial upper-airway obstruction and inter-breath transition period during sleep. Respiratory Physiology & Neurobiology, 244 32-40. doi:10.1016/j.resp.2017.06.006

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Author Mann, Dwayne L.
Edwards, Bradley A.
Joosten, Simon A.
Hamilton, Garun S.
Landry, Shane
Sands, Scott A.
Wilson, Stephen J.
Terrill, Philip I.
Title The relationship between partial upper-airway obstruction and inter-breath transition period during sleep
Journal name Respiratory Physiology & Neurobiology   Check publisher's open access policy
ISSN 1878-1519
1569-9048
Publication date 2017-10-01
Sub-type Article (original research)
DOI 10.1016/j.resp.2017.06.006
Open Access Status File (Author Post-print)
Volume 244
Start page 32
End page 40
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2800 Neuroscience
1314 Physiology
2740 Pulmonary and Respiratory Medicine
Abstract Short pauses or “transition-periods” at the end of expiration and prior to subsequent inspiration are commonly observed during sleep in humans. However, the role of transition periods in regulating ventilation during physiological challenges such as partial airway obstruction (PAO) has not been investigated. Twenty-nine obstructive sleep apnea patients and eight controls underwent overnight polysomnography with an epiglottic catheter. Sustained-PAO segments (increased epiglottic pressure over ≥5 breaths without increased peak inspiratory flow) and unobstructed reference segments were manually scored during apnea-free non-REM sleep. Nasal pressure data was computationally segmented into inspiratory (T, shortest period achieving 95% inspiratory volume), expiratory (T, shortest period achieving 95% expiratory volume), and inter-breath transition period (T, period between T and subsequent T). Compared with reference segments, sustained-PAO segments had a mean relative reduction in T (−24.7 ± 17.6%, P < 0.001), elevated T (11.8 ± 10.5%, P < 0.001), and a small reduction in T (−3.9 ± 8.0, P ≤ 0.05). Compensatory increases in inspiratory period during PAO are primarily explained by reduced transition period and not by reduced expiratory period.
Keyword Breath segmentation
Breath timing
Obstructive sleep apnea
Upper airway resistance
Ventilatory duty cycle
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1064163
15SDG25890059
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Information Technology and Electrical Engineering Publications
 
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