Investigating the relationship between iron and depression

Mills, Natalie T., Maier, Robert, Whitfield, John B., Wright, Margaret J., Colodro-Conde, Lucia, Byrne, Enda M., Scott, James G., Byrne, Gerard J., Hansell, Narelle K., Vinkhuyzen, Anna A. E., CouvyDuchesne, Baptiste, Montgomery, Grant W., Henders, Anjali K., Martin, Nicholas G., Wray, Naomi R. and Benyamin, Beben (2017) Investigating the relationship between iron and depression. Journal of Psychiatric Research, 94 148-155. doi:10.1016/j.jpsychires.2017.07.006

Author Mills, Natalie T.
Maier, Robert
Whitfield, John B.
Wright, Margaret J.
Colodro-Conde, Lucia
Byrne, Enda M.
Scott, James G.
Byrne, Gerard J.
Hansell, Narelle K.
Vinkhuyzen, Anna A. E.
CouvyDuchesne, Baptiste
Montgomery, Grant W.
Henders, Anjali K.
Martin, Nicholas G.
Wray, Naomi R.
Benyamin, Beben
Title Investigating the relationship between iron and depression
Journal name Journal of Psychiatric Research   Check publisher's open access policy
ISSN 1879-1379
Publication date 2017-11-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.jpsychires.2017.07.006
Open Access Status Not yet assessed
Volume 94
Start page 148
End page 155
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2738 Psychiatry and Mental health
2803 Biological Psychiatry
Abstract Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and depressive symptoms. Data were available from ongoing studies at QIMR Berghofer Medical Research Institute (QIMRB), including twin adolescents (mean age 15.1 years, standard deviation (SD) 3.2 years), and twin adults (mean age 23.2 years, SD 2.2 years). In the adolescent cohort, there were 3416 participants from 1688 families. In the adult cohort there were 9035 participants from 4533 families. We estimated heritabilities of, and phenotypic and genetic correlations between, traits. We conducted analyses that linked results from published large-scale genome-wide association studies (including iron and Major Depressive Disorder) with our study samples using single SNP and multi-SNP genetic risk score analyses, and LD score regression analyses. In both cohorts, measures of iron, transferrin, transferrin saturation, and log 10 of ferritin (L10Fer) were all highly heritable, while depressive measures were moderately heritable. In adolescents, depression measures were higher in those in the middle 10th versus top 10th percentile of transferrin saturation measures (p = 0.002). Genetic profile risk scores of the iron measures were not significantly associated with depression in study participants. LD score analyses showed no significant genetic relationship between iron and depression. Genetic factors strongly influence iron measures in adolescents and adults. Using several different strategies we find no evidence for a genetic contribution to the relationship between blood measures of iron and measures of depression. (C) 2017 Elsevier Ltd. All rights reserved.
Keyword Depression
Transferrin saturation
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1084417
Institutional Status UQ

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Created: Wed, 30 Aug 2017, 11:27:54 EST by Emma Schleiger on behalf of Learning and Research Services (UQ Library)