Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study

Xin Hong, Lu, Zhong Kang , Teh, Irvin , Nasrallah, Fatima Ali , Teo, Wei Peng , Ang, Kai Keng , Phua, Kok Soon , Guan, Cuntai , Chew, Efe and Chuang, Kai-Hsiang (2017) Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study. Scientific Reports, 7 1: 9222-9222. doi:10.1038/s41598-017-08928-5


Author Xin Hong
Lu, Zhong Kang
Teh, Irvin
Nasrallah, Fatima Ali
Teo, Wei Peng
Ang, Kai Keng
Phua, Kok Soon
Guan, Cuntai
Chew, Efe
Chuang, Kai-Hsiang
Title Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-08-23
Year available 2017
Sub-type Article (original research)
DOI 10.1038/s41598-017-08928-5
Open Access Status DOI
Volume 7
Issue 1
Start page 9222
End page 9222
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcortical stroke patients with unilateral upper limb disability. Nineteen patients were randomized into tDCS and sham-tDCS groups. Diffusion and perfusion MRI, and transcranial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and corticospinal excitability, respectively, before and 4 weeks after the 2-week intervention. After quality control, thirteen subjects were included in the CBF analysis. Eleven healthy controls underwent 2 sessions of MRI for reproducibility study. Whereas motor performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the tDCS group, where white matter integrity in the ipsilesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was decreased, particularly in the ipsilesional side. CBF change in the bilateral parietal cortices also correlated with motor function improvement, consistent with the increased white matter integrity in the corpus callosum connecting these regions, suggesting an involvement of interhemispheric interaction. The preliminary results indicate that tDCS may facilitate neuroplasticity and suggest the potential for refining rehabilitation strategies for stroke patients.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NIG09MAY022
Institutional Status UQ
Additional Notes Article number 9222

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Centre for Advanced Imaging Publications
 
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Created: Tue, 29 Aug 2017, 14:42:12 EST by Emma Schleiger on behalf of Queensland Brain Institute