MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

Lin, Quan, Ponnusamy, Ravikumar, Widagdo, Jocelyn, Choi, Jung A., Ge, Weihong, Probst, Christine, Buckley, Tyler, Lou, Mimi, Bredy, Timothy W., Fanselow, Michael S., Ye, Keqiang and Sun, Yi E. (2017) MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proceedings from the National Academy of Sciences of the United States of America, 114 34: 9188-9193. doi:10.1073/pnas.1706069114


Author Lin, Quan
Ponnusamy, Ravikumar
Widagdo, Jocelyn
Choi, Jung A.
Ge, Weihong
Probst, Christine
Buckley, Tyler
Lou, Mimi
Bredy, Timothy W.
Fanselow, Michael S.
Ye, Keqiang
Sun, Yi E.
Title MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life
Journal name Proceedings from the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2017-10-08
Year available 2017
Sub-type Article (original research)
DOI 10.1073/pnas.1706069114
Open Access Status Not yet assessed
Volume 114
Issue 34
Start page 9188
End page 9193
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Language eng
Abstract The prenatal period of cortical development is important for the establishment of neural circuitry and functional connectivity of the brain; however, the molecular mechanisms underlying this process remain unclear. Here we report that disruption of the actin–cytoskeletal network in the developing mouse prefrontal cortex alters dendritic morphogenesis and synapse formation, leading to enhanced formation of fear-related memory in adulthood. These effects are mediated by a brain-enriched microRNA, miR-9, through its negative regulation of diaphanous homologous protein 1 (Diap1), a key organizer of the actin cytoskeletal assembly. Our findings not only revealed important regulation of dendritogenesis and synaptogenesis during early brain development but also demonstrated a tight link between these early developmental events and cognitive functions later in life.
Keyword miR-9
Learning
Memory
Diap1
Dendritogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 91319309 | 2016YFA0100801 | 31271371 | 31471009 | 31620103904
RO1MH62122
GNT1069570
DE170100112
2014CB964602
19509
2012CB966303
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Mon, 28 Aug 2017, 12:57:23 EST by Emma Schleiger on behalf of Queensland Brain Institute