The crosstalk between ovarian cancer stem cell niche and the tumor microenvironment

Varas-Godoy, Manuel, Rice, Gregory and Illanes, Sebastian E. (2017) The crosstalk between ovarian cancer stem cell niche and the tumor microenvironment. Stem Cells International, 2017 5263974. doi:10.1155/2017/5263974


Author Varas-Godoy, Manuel
Rice, Gregory
Illanes, Sebastian E.
Title The crosstalk between ovarian cancer stem cell niche and the tumor microenvironment
Journal name Stem Cells International   Check publisher's open access policy
ISSN 1687-9678
1687-966X
Publication date 2017-07-27
Year available 2017
Sub-type Article (original research)
DOI 10.1155/2017/5263974
Open Access Status DOI
Volume 2017
Start page 5263974
Total pages 8
Place of publication New York, NY United States
Publisher Hindawi
Language eng
Subject 1312 Molecular Biology
1307 Cell Biology
Abstract Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70-80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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Created: Mon, 28 Aug 2017, 01:01:01 EST by Web Cron on behalf of UQ Centre for Clinical Research