T-1 mapping for myocardial fibrosis by cardiac magnetic resonance relaxometry - a comprehensive technical review

Hamilton-Craig, Christian R., Strudwick, Mark W. and Galloway, Graham J. (2017) T-1 mapping for myocardial fibrosis by cardiac magnetic resonance relaxometry - a comprehensive technical review. Frontiers in Cardiovascular Medicine, 3 10: 1102-1111. doi:10.3389/fcvm.2016.00049


Author Hamilton-Craig, Christian R.
Strudwick, Mark W.
Galloway, Graham J.
Title T-1 mapping for myocardial fibrosis by cardiac magnetic resonance relaxometry - a comprehensive technical review
Formatted title
T-1 mapping for myocardial fibrosis by cardiac magnetic resonance relaxometry—a comprehensive technical review
Journal name Frontiers in Cardiovascular Medicine   Check publisher's open access policy
ISSN 2297-055X
Publication date 2017-03-16
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fcvm.2016.00049
Open Access Status DOI
Volume 3
Issue 10
Start page 1102
End page 1111
Total pages 11
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract Cardiac magnetic resonance (CMR) imaging has been widely used to assess myocardial perfusion and scar and is the non-invasive gold standard for identification of focal myocardial fibrosis. However, the late gadolinium enhancement technique is limited in its accuracy for absolute quantification and assessment of diffuse myocardial fibrosis by technical and pathophysiological features. CMR relaxometry, incorporating T-1 mapping, has emerged as an accurate, reproducible, highly sensitive, and quantitative technique for the assessment of diffuse myocardial fibrosis in a number of disease states. We comprehensively review the physics behind CMR relaxometry, the evidence base, and the clinical applications of this emerging technique.
Formatted abstract
Cardiac magnetic resonance (CMR) imaging has been widely used to assess myocardial perfusion and scar and is the non-invasive gold standard for identification of focal myocardial fibrosis. However, the late gadolinium enhancement technique is limited in its accuracy for absolute quantification and assessment of diffuse myocardial fibrosis by technical and pathophysiological features. CMR relaxometry, incorporating T1 mapping, has emerged as an accurate, reproducible, highly sensitive, and quantitative technique for the assessment of diffuse myocardial fibrosis in a number of disease states. We comprehensively review the physics behind CMR relaxometry, the evidence base, and the clinical applications of this emerging technique.
Keyword T-1 mapping
Cardiac magnetic resonance
Mri
Relaxometry
Cardiovascular imaging
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID Z01 NS002989-08
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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