Manganese-based layered double hydroxide nanoparticles as a T1-MRI contrast agent with ultrasensitive pH response and high relaxivity

Li, Bei, Gu, Zi, Kurniawan, Nyoman, Chen, Weiyu and Xu, Zhi Ping (2017) Manganese-based layered double hydroxide nanoparticles as a T1-MRI contrast agent with ultrasensitive pH response and high relaxivity. Advanced Materials, 29 29: . doi:10.1002/adma.201700373


Author Li, Bei
Gu, Zi
Kurniawan, Nyoman
Chen, Weiyu
Xu, Zhi Ping
Title Manganese-based layered double hydroxide nanoparticles as a T1-MRI contrast agent with ultrasensitive pH response and high relaxivity
Journal name Advanced Materials   Check publisher's open access policy
ISSN 1521-4095
0935-9648
Publication date 2017-08-04
Year available 2017
Sub-type Article (original research)
DOI 10.1002/adma.201700373
Open Access Status Not yet assessed
Volume 29
Issue 29
Total pages 8
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Subject 2500 Materials Science
2211 Mechanics of Materials
2210 Mechanical Engineering
Abstract Recently, Mn(II)-containing nanoparticles have been explored widely as an attractive alternative to Gd(III)-based T-weighted magnetic resonance imaging (MRI) contrast agents (CAs) for cancer diagnosis. However, as far as it is known, no Mn-based MRI CAs have been reported to sensitively respond to a very weakly acidic environment (pH 6.5–7.0, i.e., the pH range in a tumor microenvironment) with satisfactory imaging performance. Here, recently devised pH-ultrasensitive Mn-based layered double hydroxide (Mn-LDH) nanoparticles with superb longitudinal relaxivity (9.48 mm s at pH 5.0 and 6.82 mm s at pH 7.0 vs 1.16 mm s at pH 7.4) are reported, which may result from the unique microstructure of Mn ions in Mn-LDH, as demonstrated by extended X-ray absorption fine structure. Further in vivo imaging reveals that Mn-LDH nanoparticles show clear MR imaging for tumor tissues in mice for 2 d post intravenous injection. Thus, this novel Mn-doped LDH nanomaterial, together with already demonstrated capacity for drug and gene delivery, is a very potential theranostic agent for cancer diagnosis and treatment.
Keyword contrast agents
high relaxivity
pH response
theranostic agents
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1073591
FT120100813
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
Centre for Advanced Imaging Publications
 
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