Shape-controlled hollow Mesoporous silica nanoparticles with multifunctional capping for in vitro cancer treatment

Geng, Hongya, Chen, Weiyu, Xu, Zhi Ping, Qian, Guangren, An, Jing and Zhang, Haijiao (2017) Shape-controlled hollow Mesoporous silica nanoparticles with multifunctional capping for in vitro cancer treatment. Chemistry: A European Journal, 23 45: 10878-10885. doi:10.1002/chem.201701806


Author Geng, Hongya
Chen, Weiyu
Xu, Zhi Ping
Qian, Guangren
An, Jing
Zhang, Haijiao
Title Shape-controlled hollow Mesoporous silica nanoparticles with multifunctional capping for in vitro cancer treatment
Journal name Chemistry: A European Journal   Check publisher's open access policy
ISSN 1521-3765
0947-6539
Publication date 2017-08-10
Year available 2017
Sub-type Article (original research)
DOI 10.1002/chem.201701806
Open Access Status Not yet assessed
Volume 23
Issue 45
Start page 10878
End page 10885
Total pages 8
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Subject 1600 Chemistry
Abstract A series of multifunctional shape-controlled nonspherical hollow mesoporous silica nanoparticles (HMSNs) drug carriers have been prepared by employing FeO with four morphologies (capsule, cube, rice, and rhombus) as a sacrificial template and a multifunctional cap as the encapsulating shell. The resulting shape-controlled nonspherical HMSNs perfectly replicate the original morphology of the FeO templates, which possess a high specific surface area, good monodispersity, perpendicular mesoporous channels, and excellent biocompatibility. After modification of polyethylene glycol (PEG) and folic acid (FA), the shape-controlled HMSN core and functional shell can then be integrated into a single device (HMSNs-PEG-FA) to provide an efficient and tumor-cell-selective drug-delivery system. The shape-controlled HMSNs and HMSNs-PEG-FA all show controlled pH-responsive release behavior for the anticancer drug doxorubicin hydrochloride (DOX). The in vitro results indicate that HMSNs-PEG-FA is biocompatible and selectively targets HeLa cells (overexpressed folate receptors). Fluorescence images show that desirable surface modification and the nonspherical shape effectively facilitate cellular internalization of HMSNs. It is expected that the construction of these unique nanomaterials with controlled morphology through the hard-templating technique may also provide useful information for the design of nanoscale multifunctional systems.
Keyword cancer
drug delivery
mesoporous materials
nanoparticles
template synthesis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 11275121
21471096
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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