Familial Melanoma Associated with Dominant Ultraviolet Radiation Sensitivity

Hockey A., Chen P., Imray F.P. and Kidson C. (1982) Familial Melanoma Associated with Dominant Ultraviolet Radiation Sensitivity. Cancer Research, 42 7: 2909-2912.

Author Hockey A.
Chen P.
Imray F.P.
Kidson C.
Title Familial Melanoma Associated with Dominant Ultraviolet Radiation Sensitivity
Journal name Cancer Research
ISSN 15387445 00085472
Publication date 1982-07-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 42
Issue 7
Start page 2909
End page 2912
Total pages 4
Language eng
Subject 2730 Oncology
1306 Cancer Research
Abstract Sensitivity to ultraviolet radiation was studied in lymphoblastoid cell lines derived from 32 members of two families with histories of multiple primary melanomas in several generations. As assayed by colony formation in agar or by trypan blue exclusion following irradiation, cellular sensitivity showed a bimodal distribution. All persons with melanoma or multiple moles were in the sensitive group, while some family members exhibited responses similar to those of controls. Cells from four cases of sporadic melanoma showed normal levels of sensitivity. The data are consistent with a dominantly inherited ultraviolet light sensitivity associated with these examples of familial melanoma. Spontaneous and ultraviolet light-induced sister chromatid exchange frequencies were similar to those in control cell lines. No defect in excision repair was detected in any of the above cell lines, but the sensitive group showed postirradiation inhibition of DNA replication intermediate between controls and an excision-deficient xeroderma pigmentosum cell line.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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