The activity of drugs against giardia intestinalis in neonatal mice

Boreham P.F.L., Phillips R.E. and Shepherd R.W. (1986) The activity of drugs against giardia intestinalis in neonatal mice. Journal of Antimicrobial Chemotherapy, 18 3: 393-398. doi:10.1093/jac/18.3.393


Author Boreham P.F.L.
Phillips R.E.
Shepherd R.W.
Title The activity of drugs against giardia intestinalis in neonatal mice
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
Publication date 1986-09-01
Sub-type Article (original research)
DOI 10.1093/jac/18.3.393
Open Access Status Not yet assessed
Volume 18
Issue 3
Start page 393
End page 398
Total pages 6
Language eng
Subject 3004 Pharmacology
2736 Pharmacology (medical)
2725 Infectious Diseases
Abstract The activities of 12 5-nitroimidazoles and ten other compounds have been compared against Giardia intestinalis stock BRIS/83/HEPU/106 in a suckling mouse model. Ronidazole, satranidazole and fexinidazole were the most active compounds being 2.8, 2.0 and 2.0 times more active than tinidazole respectively and warrant further investigation as potential chemotherapeutic agents. The results obtained in mice are consistant with the known activity of nitroimidazoles in man. There was a strong positive correlation between these results and previous in-vitro studies obtained using a 3H-thymidine uptake assay, indicating that in-vitro studies are of value in predicting in-vivo responses.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 22 Aug 2017, 00:13:21 EST by System User