Tannic acid intoxication in sheep and mice

Zhu J., Filippich L.J. and Alsalami M.T. (1992) Tannic acid intoxication in sheep and mice. Research in Veterinary Science, 53 3: 280-292. doi:10.1016/0034-5288(92)90128-O

Author Zhu J.
Filippich L.J.
Alsalami M.T.
Title Tannic acid intoxication in sheep and mice
Journal name Research in Veterinary Science   Check publisher's open access policy
ISSN 0034-5288
Publication date 1992-01-01
Sub-type Article (original research)
DOI 10.1016/0034-5288(92)90128-O
Open Access Status Not yet assessed
Volume 53
Issue 3
Start page 280
End page 292
Total pages 13
Language eng
Subject 3400 Veterinary
Abstract Acute tannic acid intoxication was studied in mice and sheep. In mice, following oral administration of 2·0 to 4·6 g of tannic acid kg bodyweight, periacinar coagulative and haemorrhagic necrosis occurred in the liver. In sheep, following oral (8 g kg bodyweight) administration of tannic acid, liver necrosis was not observed either histologically or detected biochemically, although transmission electron microscopy showed focal hepatocefular necrosis, steatosis and acicular crystal cleft formation. In sheep given tannic acid intraperitoneally (0·1 g kg bodyweight), liver necrosis occurred and plasma sodium and glucose levels significantly (P<0·05) decreased while packed cell volume and plasma aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin significantly (P<0·01) rose. The results for blood-gas and acid-base determinations, blood haemoglobin and oxygenation showed significant increases in arterial blood methaemoglobin concentration (P<0·05) and decreases in blood pH (P<0·01) and oxyhaemoglobin concentration (P<0·05) in sheep by 32 hours after oral dosing with 8 g of tannic acid kg bodyweight. In sheep given tannic acid intraperitoneally, methaemoglobinaemia was not detected, but metabolic acidosis with a compensatory respiratory alkalosis occurred. Thus, it would appear that although tannic acid is hepatotoxic when given orally to mice or intraperitoneally to sheep, it does not produce renal or significant hepatic injury in sheep when given orally, but rather causes metabolic acidosis and methaemoglobinaemia.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
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