Chemically induced intestinal damage models in zebrafish larvae

Oehlers, Stefan H., Flores, Maria Vega, Hall, Christopher J., Okuda, Kazuhide S., Sison, John Oliver, Crosier, Kathryn E. and Crosier, Philip S. (2013) Chemically induced intestinal damage models in zebrafish larvae. Zebrafish, 10 2: 184-193. doi:10.1089/zeb.2012.0824


Author Oehlers, Stefan H.
Flores, Maria Vega
Hall, Christopher J.
Okuda, Kazuhide S.
Sison, John Oliver
Crosier, Kathryn E.
Crosier, Philip S.
Title Chemically induced intestinal damage models in zebrafish larvae
Journal name Zebrafish   Check publisher's open access policy
ISSN 1545-8547
Publication date 2013-06-01
Sub-type Article (original research)
DOI 10.1089/zeb.2012.0824
Open Access Status Not yet assessed
Volume 10
Issue 2
Start page 184
End page 193
Total pages 10
Place of publication New Rochelle, NY United States
Publisher Mary Ann Liebert
Language eng
Abstract Several intestinal damage models have been developed using zebrafish, with the aim of recapitulating aspects of human inflammatory bowel disease (IBD). These experimentally induced inflammation models have utilized immersion exposure to an array of colitogenic agents (including live bacteria, bacterial products, and chemicals) to induce varying severity of inflammation. This technical report describes methods used to generate two chemically induced intestinal damage models using either dextran sodium sulfate (DSS) or trinitrobenzene sulfonic acid (TNBS). Methods to monitor intestinal damage and inflammatory processes, and chemical-genetic methods to manipulate the host response to injury are also described.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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