Mast cells in human periodontal disease

Gemmell, E., Carter, C. L. and Seymour, G. J. (2004) Mast cells in human periodontal disease. Journal of Dental Research, 83 5: 384-387. doi:10.1177/154405910408300506

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Author Gemmell, E.
Carter, C. L.
Seymour, G. J.
Title Mast cells in human periodontal disease
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1177/154405910408300506
Open Access Status File (Author Post-print)
Volume 83
Issue 5
Start page 384
End page 387
Total pages 4
Editor Mark Herzberg
Place of publication USA
Publisher American Assoc for Dental Research
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Recently, mast cells have been shown to produce cytokines which can direct the development of T-cell subsets. The aim of the present study was to determine the relationship between mast cells and the Th1/Th2 response in human periodontal disease. Tryptase+ mast cell numbers were decreased in chronic periodontitis tissues compared with healthy/gingivitis lesions. Lower numbers of c-kit+ cells, which remained constant regardless of clinical status, indicate that there may be no increased migration of mast cells into periodontal disease lesions. While there were no differences in IgG2+ or IgG4+ cell numbers in healthy/gingivitis samples, there was an increase in IgG4+ cells compared with IgG2+ cells in periodontitis lesions, numbers increasing with disease severity. This suggests a predominance of Th2 cells in periodontitis, although mast cells may not be the source of Th2-inducing cytokines.
Keyword Dentistry, Oral Surgery & Medicine
Mast Cells
Periodontal Disease
Immunohistology
Interferon-gamma
T-lymphocytes
Interleukin-3
Expression
Growth
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 33 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 12:57:34 EST