Evanescent single-molecule biosensing with quantum-limited precision

Mauranyapin, N. P., Madsen, L. S., Taylor, M. A., Waleed, M. and Bowen, W. P. (2017) Evanescent single-molecule biosensing with quantum-limited precision. Nature Photonics, 11 8: 477-481. doi:10.1038/nphoton.2017.99

Author Mauranyapin, N. P.
Madsen, L. S.
Taylor, M. A.
Waleed, M.
Bowen, W. P.
Title Evanescent single-molecule biosensing with quantum-limited precision
Journal name Nature Photonics   Check publisher's open access policy
ISSN 1749-4893
Publication date 2017-08-01
Year available 2017
Sub-type Article (original research)
DOI 10.1038/nphoton.2017.99
Open Access Status Not yet assessed
Volume 11
Issue 8
Start page 477
End page 481
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Sensors that are able to detect and track single unlabelled biomolecules are an important tool to understand biomolecular dynamics and interactions as well as for medical diagnostics operating at their ultimate detection limits(1-7). Recently, exceptional sensitivity has been achieved using the strongly enhanced evanescent fields provided by optical microcavities(2,4,5,8) and plasmonic resonators(1,6,7). However, at high field intensities, photodamage to the biological specimen becomes increasingly problematic(9-12). Here, we introduce an evanescent biosensor that operates at the fundamental precision limit due to the quantization of light. This allows a four orders of magnitude reduction in optical intensity, while maintaining state-of-the-art sensitivity. It enables quantum noise-limited tracking of single biomolecules as small as 3.5 nm, and monitoring of surface-molecule interactions over extended periods. By achieving quantum noise-limited precision, our approach provides a path towards quantum-enhanced single-molecule biosensors.
Keyword Whispering-Gallery Mode
Nanoparticle Detection
Optical Microcavities
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP140100734
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
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