Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors

Zheng, Bo, Xie, Fengwei, Situ, Wenbei, Chen, Ling and Li, Xiaoxi (2017) Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors. Journal of Functional Foods, 37 272-282. doi:10.1016/j.jff.2017.07.048


Author Zheng, Bo
Xie, Fengwei
Situ, Wenbei
Chen, Ling
Li, Xiaoxi
Title Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors
Journal name Journal of Functional Foods   Check publisher's open access policy
ISSN 1756-4646
2214-9414
Publication date 2017-10-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.jff.2017.07.048
Open Access Status Not yet assessed
Volume 37
Start page 272
End page 282
Total pages 11
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Abstract A new carrier system for controlled release of immunologic peptides based on double polysaccharide film-coated microparticles (PCMPs) used with liquid products was developed. The release behavior of PCMPs was shown dependent on the thicknesses of the outer chitosan film and the inner resistant starch acetate (RSA) film. The in-vitro release results indicated that, with optimized polysaccharide coating thickness (RSA: 4-5%; chitosan: 6-7%), the release rate of Thymopoietin (TP5) was less than 30% before the microparticles reached the colon, and was 50% in the colon. Besides, the bioavailability of PCMPs was evaluated based on the cell proliferation and protein expression. Compared with the intraperitoneal injection or oral administration, the immunodeficient rats that were orally administrated with the yogurt containing TP5-loaded PCMPs with different storage times possessed a good colon-targeting behavior, higher ratios of CD4/CD8 and IgG expression, indicating the improvement in the TP5 immunologic function. (C) 2017 Elsevier Ltd. All rights reserved.
Keyword Chitosan
Colon-targeting
Controlled release
Liquid products
pH-responsiveness
Resistant starch acetate
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID U1501214
2014YT02S029
2014B090904047
201607010109
2014A2FC217
2015KTSCX006
2015ZZ106
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
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