Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

Gracia-Lor, Emma, Rousis, Nikolaos I., Zuccato, Ettore, Bade, Richard, Baz-Lomba, Jose Antonio, Castrignano, Erika, Causanilles, Ana, Hernandez, Félix, Kasprzyk-Hordern, Barbara, Kinyua, Juliet, McCall, Ann-Kathrin, van Nuijs, Alexander L. N., Plosz, Benedek G., Ramin, Pedram, Ryu, Yeonsuk, Santos, Miguel M., Thomas, Kevin, de Voogt, Pim, Yang, Zhugen and Castiglioni, Sara (2017) Estimation of caffeine intake from analysis of caffeine metabolites in wastewater. Science of the Total Environment, 609 1582-1588. doi:10.1016/j.scitotenv.2017.07.258

Author Gracia-Lor, Emma
Rousis, Nikolaos I.
Zuccato, Ettore
Bade, Richard
Baz-Lomba, Jose Antonio
Castrignano, Erika
Causanilles, Ana
Hernandez, Félix
Kasprzyk-Hordern, Barbara
Kinyua, Juliet
McCall, Ann-Kathrin
van Nuijs, Alexander L. N.
Plosz, Benedek G.
Ramin, Pedram
Ryu, Yeonsuk
Santos, Miguel M.
Thomas, Kevin
de Voogt, Pim
Yang, Zhugen
Castiglioni, Sara
Title Estimation of caffeine intake from analysis of caffeine metabolites in wastewater
Journal name Science of the Total Environment   Check publisher's open access policy
ISSN 1879-1026
Publication date 2017-12-31
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.scitotenv.2017.07.258
Open Access Status Not yet assessed
Volume 609
Start page 1582
End page 1588
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2305 Environmental Engineering
2304 Environmental Chemistry
2311 Waste Management and Disposal
2310 Pollution
Abstract Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.
Keyword 1,7-dimethyluric acid
Correction factor
Urinary biomarkers
Wastewater-based epidemiology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 317205
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Alliance for Environmental Health Sciences (QAEHS) Publications
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