Brain changes following four weeks of unimanual motor training: evidence from behavior, neural stimulation, cortical thickness, and functional MRI

Sale, Martin V., Reid, Lee B., Cocchi, Luca, Pagnozzi, Alex M., Rose, Stephen E. and Mattingley, Jason B. (2017) Brain changes following four weeks of unimanual motor training: evidence from behavior, neural stimulation, cortical thickness, and functional MRI. Human Brain Mapping, 38 9: 4773-4787. doi:10.1002/hbm.23710


Author Sale, Martin V.
Reid, Lee B.
Cocchi, Luca
Pagnozzi, Alex M.
Rose, Stephen E.
Mattingley, Jason B.
Title Brain changes following four weeks of unimanual motor training: evidence from behavior, neural stimulation, cortical thickness, and functional MRI
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
1097-0193
Publication date 2017-07-05
Sub-type Article (original research)
DOI 10.1002/hbm.23710
Open Access Status Not yet assessed
Volume 38
Issue 9
Start page 4773
End page 4787
Total pages 15
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Although different aspects of neuroplasticity can be quantified with behavioral probes, brain stimulation, and brain imaging assessments, no study to date has combined all these approaches into one comprehensive assessment of brain plasticity. Here, 24 healthy right-handed participants practiced a sequence of finger-thumb opposition movements for 10 min each day with their left hand. After 4 weeks, performance for the practiced sequence improved significantly (P<0.05 FWE) relative to a matched control sequence, with both the left (mean increase: 53.0% practiced, 6.5% control) and right (21.0%; 15.8%) hands. Training also induced significant (cluster p-FWE<0.001) reductions in functional MRI activation for execution of the trained sequence, relative to the control sequence. These changes were observed as clusters in the premotor and supplementary motor cortices (right hemisphere, 301 voxel cluster; left hemisphere 700 voxel cluster), and sensorimotor cortices and superior parietal lobules (right hemisphere 864 voxel cluster; left hemisphere, 1947 voxel cluster). Transcranial magnetic stimulation over the right ("trained") primary motor cortex yielded a 58.6% mean increase in a measure of motor evoked potential amplitude, as recorded at the left abductor pollicis brevis muscle. Cortical thickness analyses based on structural MRI suggested changes in the right precentral gyrus, right post central gyrus, right dorsolateral prefrontal cortex, and potentially the right supplementary motor area. Such findings are consistent with LTP-like neuroplastic changes in areas that were already responsible for finger sequence execution, rather than improved recruitment of previously nonutilized tissue.
Keyword Cortical thickness
Functional magnetic resonance imaging
Magnetic resonance imaging
Motor
Motor cortex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 10 Aug 2017, 10:34:49 EST by Dr Martin Sale on behalf of School of Health & Rehabilitation Sciences