Brain changes following four weeks of unimanual motor training: Evidence from fMRI-guided diffusion MRI tractography

Reid, Lee B. , Sale, Martin V. , Cunnington, Ross , Mattingley, Jason B. and Rose, Stephen E. (2017) Brain changes following four weeks of unimanual motor training: Evidence from fMRI-guided diffusion MRI tractography. Human Brain Mapping, 38 9: 4302-4312. doi:10.1002/hbm.23514


Author Reid, Lee B.
Sale, Martin V.
Cunnington, Ross
Mattingley, Jason B.
Rose, Stephen E.
Title Brain changes following four weeks of unimanual motor training: Evidence from fMRI-guided diffusion MRI tractography
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1097-0193
1065-9471
Publication date 2017-09-01
Year available 2017
Sub-type Article (original research)
DOI 10.1002/hbm.23514
Open Access Status Not yet assessed
Volume 38
Issue 9
Start page 4302
End page 4312
Total pages 11
Place of publication Hoboken, NJ United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
We have reported reliable changes in behavior, brain structure, and function in 24 healthy right-handed adults who practiced a finger-thumb opposition sequence task with their left hand for 10 min daily, over 4 weeks. Here, we extend these findings by using diffusion MRI to investigate white-matter changes in the corticospinal tract, basal-ganglia, and connections of the dorsolateral prefrontal cortex. Twenty-three participant datasets were available with pre-training and post-training scans. Task performance improved in all participants (mean: 52.8%, SD: 20.0%; group P < 0.01 FWE) and widespread microstructural changes were detected across the motor system of the “trained” hemisphere. Specifically, region-of-interest-based analyses of diffusion MRI (n = 22) revealed significantly increased fractional anisotropy (FA) in the right caudate nucleus (4.9%; P < 0.05 FWE), and decreased mean diffusivity in the left nucleus accumbens (−1.3%; P < 0.05 FWE). Diffusion MRI tractography (n = 22), seeded by sensorimotor cortex fMRI activation, also revealed increased FA in the right corticospinal tract (mean 3.28%; P < 0.05 FWE) predominantly reflecting decreased radial diffusivity. These changes were consistent throughout the entire length of the tract. The left corticospinal tract did not show any changes. FA also increased in white matter connections between the right middle frontal gyrus and both right caudate nucleus (17/22 participants; P < 0.05 FWE) and right supplementary motor area (18/22 participants; P < 0.05 FWE). Equivalent changes in FA were not seen in the left (non-trained) hemisphere. In combination with our functional and structural findings, this study provides detailed, multifocal evidence for widespread neuroplastic changes in the human brain resulting from motor training.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Thu, 10 Aug 2017, 10:30:13 EST by Dr Martin Sale on behalf of School of Health & Rehabilitation Sciences