The nature of microsomal monooxygenase inhibition by cimetidine

Winzor D.J., Ioannoni B. and Reilly P.E.B. (1986) The nature of microsomal monooxygenase inhibition by cimetidine. Biochemical Pharmacology, 35 13: 2157-2161. doi:10.1016/0006-2952(86)90586-1


Author Winzor D.J.
Ioannoni B.
Reilly P.E.B.
Title The nature of microsomal monooxygenase inhibition by cimetidine
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 1986-07-01
Sub-type Article (original research)
DOI 10.1016/0006-2952(86)90586-1
Open Access Status Not yet assessed
Volume 35
Issue 13
Start page 2157
End page 2161
Total pages 5
Language eng
Subject 1303 Biochemistry
3004 Pharmacology
Abstract A kinetic investigation of the inhibitory effect of cimetidine on the O-dealkylation of 7-ethoxyresorufin by rat liver microsomes has yielded linear Lineweaver-Burk plots which intersect in the second quadrant. Though technically compatible with non-competitive inhibition, the results are shown to be readily explained by the more realistic molecular concept of competitive inhibition by invoking the involvement of cytochrome P-450 isoenzymes with widely different K values. Microsomal monooxygenase heterogeneity is also shown to provide a plausible explanation of other published results signifying the departure of chloramphenicol and phenacetin from the concept of competitive inhibition despite competition with substrate for the active-site haem group of cytochrome P-450.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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