Cell dynamics in the olfactory epithelium of the tiger salamander: a morphometric analysis

Mackay-Sim A., Breipohl W. and Kremer M. (1988) Cell dynamics in the olfactory epithelium of the tiger salamander: a morphometric analysis. Experimental Brain Research, 71 1: 189-198. doi:10.1007/BF00247534


Author Mackay-Sim A.
Breipohl W.
Kremer M.
Title Cell dynamics in the olfactory epithelium of the tiger salamander: a morphometric analysis
Journal name Experimental Brain Research   Check publisher's open access policy
ISSN 0014-4819
Publication date 1988-06-01
Sub-type Article (original research)
DOI 10.1007/BF00247534
Open Access Status
Volume 71
Issue 1
Start page 189
End page 198
Total pages 10
Publisher Springer-Verlag
Language eng
Subject 2800 Neuroscience
Abstract The factors controlling neurogenesis and differentiation of olfactory receptor cells in adults are poorly understood, although it is often stated that these cells undergo continual turnover after a pre-determined lifespan. An interesting model in which to study mechanisms which control olfactory receptor neurogenesis and cell turnover is the tiger salamander, since basal cell mitosis varies with epithelial thickness and location in the nasal cavity. This paper presents a quantitative light-microscopic study of the different cell types within the ventral olfactory epithelium of the tiger salamander using a computer-assisted morphometric analysis of 2 μm sections. The results show that the surface density of olfactory vesicles remained constant throughout most of the epithelium and was independent of nasal cavity location, epithelial thickness and the total number of nuclei per unit epithelial surface area. Histological classification of nuclei into different cell types indicated that the increase in total cell number with epithelial thickness was mainly due to an increase in the number of immature receptor cells since the number of supporting cells varied only slightly and the numbers of basal cells and mature receptor cells remained constant except in the thinnest, most caudally located epithelium. It is concluded that the rate of maturation of receptor cells may be limited by an optimal surface density of olfactory vesicles. That is, when this density reaches 4.5×10 vesicles per mm there is a physical or chemical mechanism which prevents the final maturation of newly developing receptor cells, leading to their accumulation. This mechanism may also account for the variations in basal cell mitosis in this species.
Keyword Neural development
Neurogenesis
Olfactory receptor cell
Tiger salamander
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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