The validity of a new structured assessment of gastrointestinal symptoms scale (SAGIS) for evaluating symptoms in the clinical setting

Koloski, N. A., Jones, M., Hammer, J., von Wulffen, M., Shah, A., Hoelz, H., Kutyla, M., Burger, D., Martin, N., Gurusamy, S. R., Talley, N. J. and Holtmann, G. (2017) The validity of a new structured assessment of gastrointestinal symptoms scale (SAGIS) for evaluating symptoms in the clinical setting. Digestive Diseases and Sciences, 62 8: 1913-1922. doi:10.1007/s10620-017-4599-6

Author Koloski, N. A.
Jones, M.
Hammer, J.
von Wulffen, M.
Shah, A.
Hoelz, H.
Kutyla, M.
Burger, D.
Martin, N.
Gurusamy, S. R.
Talley, N. J.
Holtmann, G.
Title The validity of a new structured assessment of gastrointestinal symptoms scale (SAGIS) for evaluating symptoms in the clinical setting
Journal name Digestive Diseases and Sciences   Check publisher's open access policy
ISSN 1573-2568
Publication date 2017-08-01
Sub-type Article (original research)
DOI 10.1007/s10620-017-4599-6
Open Access Status Not yet assessed
Volume 62
Issue 8
Start page 1913
End page 1922
Total pages 10
Place of publication New York, NY, United States
Publisher Springer New York LLC
Language eng
Subject 1314 Physiology
2715 Gastroenterology
Abstract Background: The clinical assessments of patients with gastrointestinal symptoms can be time-consuming, and the symptoms captured during the consultation may be influenced by a variety of patient and non-patient factors. To facilitate standardized symptom assessment in the routine clinical setting, we developed the Structured Assessment of Gastrointestinal Symptom (SAGIS) instrument to precisely characterize symptoms in a routine clinical setting. Aims: We aimed to validate SAGIS including its reliability, construct and discriminant validity, and utility in the clinical setting. Methods: Development of the SAGIS consisted of initial interviews with patients referred for the diagnostic work-up of digestive symptoms and relevant complaints identified. The final instrument consisted of 22 items as well as questions on extra intestinal symptoms and was given to 1120 consecutive patients attending a gastroenterology clinic randomly split into derivation (n = 596) and validation datasets (n = 551). Discriminant validity along with test–retest reliability was assessed. The time taken to perform a clinical assessment with and without the SAGIS was recorded along with doctor satisfaction with this tool. Results: Exploratory factor analysis conducted on the derivation sample suggested five symptom constructs labeled as abdominal pain/discomfort (seven items), gastroesophageal reflux disease/regurgitation symptoms (four items), nausea/vomiting (three items), diarrhea/incontinence (five items), and difficult defecation and constipation (2 items). Confirmatory factor analysis conducted on the validation sample supported the initially developed five-factor measurement model (χ1932=892.2, p < 0.0001, χ/df = 4.6, CFI = 0.90, TLI = 0.88, RMSEA = 0.08). All symptom groups demonstrated differentiation between disease groups. The SAGIS was shown to be reliable over time and resulted in a 38% reduction of the time required for clinical assessment. Conclusions: The SAGIS instrument has excellent psychometric properties and supports the clinical assessment of and symptom-based categorization of patients with a wide spectrum of gastrointestinal symptoms.
Keyword Gastrointestinal symptoms
Irritable bowel syndrome
Quality of life
Questionnaire development
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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