Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation

Moeller, Alexander, Carlsen, Kai-Hakon, Sly, Peter D., Baraldi, Eugenio, Piacentini, Giorgio, Pavord, Ian, Lex, Christiane, Saglani, Sejal, Brand, Paul L. P., Eber, Ernst, Frischer, Thomas, Hedlin, Gunilla, Kulkarni, Neeta, Lodrup Carlsen, Karin C., Makela, Mika J., Mantzouranis, Eva, Pijnenburg, Mariëlle W., Price, David, Rottier, Bart L., Szefler, Stanley J., Turner, Steve and Wooler, Edwina (2015) Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation. European Respiratory Review, 24 136: 204-215. doi:10.1183/16000617.00003914

Author Moeller, Alexander
Carlsen, Kai-Hakon
Sly, Peter D.
Baraldi, Eugenio
Piacentini, Giorgio
Pavord, Ian
Lex, Christiane
Saglani, Sejal
Brand, Paul L. P.
Eber, Ernst
Frischer, Thomas
Hedlin, Gunilla
Kulkarni, Neeta
Lodrup Carlsen, Karin C.
Makela, Mika J.
Mantzouranis, Eva
Pijnenburg, Mariëlle W.
Price, David
Rottier, Bart L.
Szefler, Stanley J.
Turner, Steve
Wooler, Edwina
Title Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation
Journal name European Respiratory Review   Check publisher's open access policy
ISSN 1600-0617
Publication date 2015-06-01
Sub-type Article (original research)
DOI 10.1183/16000617.00003914
Open Access Status DOI
Volume 24
Issue 136
Start page 204
End page 215
Total pages 12
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
Abstract This review focuses on the methods available for measuring reversible airways obstruction, bronchial hyperresponsiveness (BHR) and inflammation as hallmarks of asthma, and their role in monitoring children with asthma. Persistent bronchial obstruction may occur in asymptomatic children and is considered a risk factor for severe asthma episodes and is associated with poor asthma outcome. Annual measurement of forced expiratory volume in 1 s using office based spirometry is considered useful. Other lung function measurements including the assessment of BHR may be reserved for children with possible exercise limitations, poor symptom perception and those not responding to their current treatment or with atypical asthma symptoms, and performed on a higher specialty level. To date, for most methods of measuring lung function there are no proper randomised controlled or large longitudinal studies available to establish their role in asthma management in children. Noninvasive biomarkers for monitoring inflammation in children are available, for example the measurement of exhaled nitric oxide fraction, and the assessment of induced sputum cytology or inflammatory mediators in the exhaled breath condensate. However, their role and usefulness in routine clinical practice to monitor and guide therapy remains unclear, and therefore, their use should be reserved for selected cases.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Child Health Research Centre Publications
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