Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

Gibson, Peter G., Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Powell, Heather, Taylor, Steven L., Leong, Lex E. X., Rogers, Geraint B. and Simpson, Jodie L. (2017) Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. The Lancet, 390 10095: 659-668. doi:10.1016/S0140-6736(17)31281-3


Author Gibson, Peter G.
Yang, Ian A.
Upham, John W.
Reynolds, Paul N.
Hodge, Sandra
James, Alan L.
Jenkins, Christine
Peters, Matthew J.
Marks, Guy B.
Baraket, Melissa
Powell, Heather
Taylor, Steven L.
Leong, Lex E. X.
Rogers, Geraint B.
Simpson, Jodie L.
Title Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial
Journal name The Lancet   Check publisher's open access policy
ISSN 1474-547X
0140-6736
Publication date 2017-08-12
Year available 2017
Sub-type Article (original research)
DOI 10.1016/S0140-6736(17)31281-3
Open Access Status Not yet assessed
Volume 390
Issue 10095
Start page 659
End page 668
Total pages 10
Place of publication London, United Kingdom
Publisher Lancet Publishing Group
Language eng
Subject 2700 Medicine
Abstract Background Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can be used to treat persistent asthma, we aimed to assess the efficacy and safety of oral azithromycin as add-on therapy in patients with uncontrolled persistent asthma on medium-to-high dose inhaled corticosteroids plus a long-acting bronchodilator.
Keyword Medicine, General & Internal
General & Internal Medicine
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 569246
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Faculty of Medicine
School of Clinical Medicine Publications
Admin Only - School of Clinical Medicine
 
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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