A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion and Morphine Sulfate (BEAMS) study protocol

Currow, David, Watts, Gareth John, Johnson, Miriam, McDonald, Christine F., Miners, John O., Somogyi, Andrew A., Denehy, Linda, McCaffrey, Nicola, Eckert, Danny J., McCloud, Philip, Louw, Sandra, Lam, Lawrence, Greene, Aine, Fazekas, Belinda, Clark, Katherine C., Fong, Kwun, Agar, Meera R., Joshi, Rohit, Kilbreath, Sharon, Ferreira, Diana and Ekström, Magnus (2017) A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion and Morphine Sulfate (BEAMS) study protocol. BMJ Open, 7 7: e018100. doi:10.1136/bmjopen-2017-018100


Author Currow, David
Watts, Gareth John
Johnson, Miriam
McDonald, Christine F.
Miners, John O.
Somogyi, Andrew A.
Denehy, Linda
McCaffrey, Nicola
Eckert, Danny J.
McCloud, Philip
Louw, Sandra
Lam, Lawrence
Greene, Aine
Fazekas, Belinda
Clark, Katherine C.
Fong, Kwun
Agar, Meera R.
Joshi, Rohit
Kilbreath, Sharon
Ferreira, Diana
Ekström, Magnus
Title A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion and Morphine Sulfate (BEAMS) study protocol
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2017-07-01
Year available 2017
Sub-type Article (original research)
DOI 10.1136/bmjopen-2017-018100
Open Access Status DOI
Volume 7
Issue 7
Start page e018100
Total pages 19
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2700 Medicine
Abstract Introduction Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended-release (ER) oral morphine. A recent large phase III study suggests the subgroup most likely to benefit have chronic obstructive pulmonary disease (COPD) and modified Medical Research Council breathlessness scores of 3 or 4. This protocol is for an adequately powered, parallel-arm, placebo-controlled, multisite, factorial, block-randomised study evaluating regular ER morphine for chronic breathlessness in people with COPD.
Keyword Chronic breathlessness
Opioids
Palliative care
Protocol
Randomised control trial
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1065571
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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