Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

Vanwalleghem, Gilles, Morias, Yannick, Beschin, Alain, Szymkowski, David E. and Pays, Etienne (2017) Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine. Scientific Reports, 7 1: 6165.1-6165.7. doi:10.1038/s41598-017-06496-2


Author Vanwalleghem, Gilles
Morias, Yannick
Beschin, Alain
Szymkowski, David E.
Pays, Etienne
Title Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-12-01
Year available 2017
Sub-type Article (original research)
DOI 10.1038/s41598-017-06496-2
Open Access Status DOI
Volume 7
Issue 1
Start page 6165.1
End page 6165.7
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growth, but also to contribute to tissue damage, shortening the survival time of infected mice. Using a dominant-negative version of TNF to discriminate between the effects of the membrane-form versus the soluble form of TNF, we show that the second form is involved in neither parasite control nor induction of liver injury. Therefore, soluble TNF is likely not a major contributor to disease outcome. We propose that membrane-bound TNF is responsible for both T. brucei control and host pathology.
Formatted abstract
Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growth, but also to contribute to tissue damage, shortening the survival time of infected mice. Using a dominant-negative version of TNF to discriminate between the effects of the membrane-form versus the soluble form of TNF, we show that the second form is involved in neither parasite control nor induction of liver injury. Therefore, soluble TNF is likely not a major contributor to disease outcome. We propose that membrane-bound TNF is responsible for both T. brucei control and host pathology.
Keyword Trypanosoma brucei
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 669007
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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