Sodium channels and pain: from toxins to therapies

Fernanda Caldas Cardoso and Lewis, Richard J. (2017) Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology, . doi:10.1111/bph.13962


Author Fernanda Caldas Cardoso
Lewis, Richard J.
Title Sodium channels and pain: from toxins to therapies
Journal name British Journal of Pharmacology   Check publisher's open access policy
ISSN 14765381 00071188
Publication date 2017-07-27
Sub-type Article (original research)
DOI 10.1111/bph.13962
Open Access Status Not Open Access
Total pages 1
Publisher John Wiley and Sons Inc.
Language eng
Abstract Voltage-gated sodium channels (NaV channels) are essential for the initiation and propagation of action potentials that critically influence our ability to respond to a diverse range of stimuli. Physiological and pharmacological studies have linked abnormal function of NaV channels to many human disorders, including chronic neuropathic pain. These findings, along with the description of the functional properties and expression pattern of NaV channel subtypes, are helping to uncover subtype specific roles in acute and chronic pain and revealing potential opportunities to target these with selective inhibitors. High-throughput screens and automated electrophysiology platforms have identified natural toxins as a promising group of molecules for the development of target-specific analgesics. In this review, the role of toxins in defining the contribution of NaV channels in acute and chronic pain states and their potential to be used as analgesic therapies are discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Mon, 31 Jul 2017, 12:08:12 EST by Fernanda Caldas Cardoso on behalf of Institute for Molecular Bioscience