Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben, Brage, Soren, Cheng, Yu-Ching, Cieszczyk, Pawel, Derave, Wim, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Lucia, Alejandro, Massidda, Myosotis, Mitchell, Braxton D., Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Loannis, Rajpal, Deepak K., Sale, Craig, Schnurr, Theresia M., Sessa, Francesco, Shrine, Nick, Tobin, Martin D., Varley, Ian, Wain, Louise V., Wray, Naomi R., Lindgren, Cecilia M., MacArthur, Daniel G., Waterworth, Dawn M., McCarthy, Mark I., Pedersen, Oluf, Khaw, Kay-Tee, Kie, Douglas P., Pitsiladis, Yannis, Fuku, Noriyuki, Franks, Paul W., North, Kathryn N., van Duijn, Cornelia M., Mather, Karen A., Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M., Richards, J. Brent, Rivadeneira, Fernando, Langenberg, Claudia, Perry, John R. B., Wareham, Nick J., Scott, Robert A., GEFOS Any-Type of Fracture Consortium, Oei, Ling, Zheng, Hou-Feng, Forgetta, Vincenzo, Leong, Aaron, Ahmad, Omar S., Laurin, Charles, Mokry, Lauren E., Ross, Stephanie, Elks, Cathy E., Bowden, Jack, Warrington, Nicole M., Murray, Anna, Ruth, Katherine S., Tsilidis, Konstantinos K., Medina-Gomez, Carolina, Estrada, Karol, Bis, Joshua C., Chasman, Daniel I., Demissie, Serkalem, Enneman, Anke W., Hsu, Yi-Hsiang, Ingvarsson, Thorvaldur, Kaehoenen, Mika, Kammerer, Candace, Lacroix, Andrea Z., Li, Guo, Liu, Ching-Ti, Liu, Yongmei, Lorentzon, Mattias, Maegi, Reedik, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Nielson, Carrie M., Sham, Pack Chung, Siggeirsdotir, Kristin, Sigurdsson, Gunnar, Stefansson, Kari, Trompet, Stella, Thorleifsson, Gudmar, Vandenput, Liesbeth, van der Velde, Nathalie, Viikari, Jorma, Xiao, Su-Mei, Zhao, Jing Hua, Evans, Daniel S, Cummings, Steven R., Cauley, Jane, Duncan, Emma L., de Groot, Lisette C. P. G. M., Esko, Tonu, Gudnason, Vilmundar, Harris, Tamara B., Jackson, Rebecca D., Jukema, J. Wouter, Ikram, Arfan M. A., Karasik, David, Kaptoge, Stephen, Kung, Annie Wai Chee, Lehtimaeki, Terho, Lyytikaeinen, Leo-Pekka, Lips, Paul, Luben, Robert, Metspalu, Andres, van Meurs, Joyce B. J., Minster, Ryan L., Orwoll, Erick, Oei, Edwin, Psaty, Bruce M., Raitakari, Olli T., Ralston, Stuart W., Ridker, Paul M., Robbins, John A., Smith, Albert V., Styrkarsdottir, Unnur, Tranah, Gregory J., Thorstensdottir, Unnur, Uitterlinden, Andre G., Zmuda, Joseph, Zillikens, M. Carola, Ntzani, Evangelia E., Evangelou, Evangelos, Ioannidis, John P. A., Evans, David M. and Ohlsson, Claes (2017) Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 . doi:10.1038/ncomms16015


Author Willems, Sara M.
Wright, Daniel J.
Day, Felix R.
Trajanoska, Katerina
Joshi, Peter K.
Morris, John A.
Matteini, Amy M.
Garton, Fleur C.
Grarup, Niels
Oskolkov, Nikolay
Thalamuthu, Anbupalam
Mangino, Massimo
Liu, Jun
Demirkan, Ayse
Lek, Monkol
Xu, Liwen
Wang, Guan
Oldmeadow, Christopher
Gaulton, Kyle J.
Lotta, Luca A.
Miyamoto-Mikami, Eri
Rivas, Manuel A.
White, Tom
Loh, Po-Ru
Aadahl, Mette
Amin, Najaf
Attia, John R.
Austin, Krista
Benyamin, Beben
Brage, Soren
Cheng, Yu-Ching
Cieszczyk, Pawel
Derave, Wim
Eriksson, Karl-Fredrik
Eynon, Nir
Linneberg, Allan
Lucia, Alejandro
Massidda, Myosotis
Mitchell, Braxton D.
Miyachi, Motohiko
Murakami, Haruka
Padmanabhan, Sandosh
Pandey, Ashutosh
Papadimitriou, Loannis
Rajpal, Deepak K.
Sale, Craig
Schnurr, Theresia M.
Sessa, Francesco
Shrine, Nick
Tobin, Martin D.
Varley, Ian
Wain, Louise V.
Wray, Naomi R.
Lindgren, Cecilia M.
MacArthur, Daniel G.
Waterworth, Dawn M.
McCarthy, Mark I.
Pedersen, Oluf
Khaw, Kay-Tee
Kie, Douglas P.
Pitsiladis, Yannis
Fuku, Noriyuki
Franks, Paul W.
North, Kathryn N.
van Duijn, Cornelia M.
Mather, Karen A.
Hansen, Torben
Hansson, Ola
Spector, Tim
Murabito, Joanne M.
Richards, J. Brent
Rivadeneira, Fernando
Langenberg, Claudia
Perry, John R. B.
Wareham, Nick J.
Scott, Robert A.
GEFOS Any-Type of Fracture Consortium
Oei, Ling
Zheng, Hou-Feng
Forgetta, Vincenzo
Leong, Aaron
Ahmad, Omar S.
Laurin, Charles
Mokry, Lauren E.
Ross, Stephanie
Elks, Cathy E.
Bowden, Jack
Warrington, Nicole M.
Murray, Anna
Ruth, Katherine S.
Tsilidis, Konstantinos K.
Medina-Gomez, Carolina
Estrada, Karol
Bis, Joshua C.
Chasman, Daniel I.
Demissie, Serkalem
Enneman, Anke W.
Hsu, Yi-Hsiang
Ingvarsson, Thorvaldur
Kaehoenen, Mika
Kammerer, Candace
Lacroix, Andrea Z.
Li, Guo
Liu, Ching-Ti
Liu, Yongmei
Lorentzon, Mattias
Maegi, Reedik
Mihailov, Evelin
Milani, Lili
Moayyeri, Alireza
Nielson, Carrie M.
Sham, Pack Chung
Siggeirsdotir, Kristin
Sigurdsson, Gunnar
Stefansson, Kari
Trompet, Stella
Thorleifsson, Gudmar
Vandenput, Liesbeth
van der Velde, Nathalie
Viikari, Jorma
Xiao, Su-Mei
Zhao, Jing Hua
Evans, Daniel S
Cummings, Steven R.
Cauley, Jane
Duncan, Emma L.
de Groot, Lisette C. P. G. M.
Esko, Tonu
Gudnason, Vilmundar
Harris, Tamara B.
Jackson, Rebecca D.
Jukema, J. Wouter
Ikram, Arfan M. A.
Karasik, David
Kaptoge, Stephen
Kung, Annie Wai Chee
Lehtimaeki, Terho
Lyytikaeinen, Leo-Pekka
Lips, Paul
Luben, Robert
Metspalu, Andres
van Meurs, Joyce B. J.
Minster, Ryan L.
Orwoll, Erick
Oei, Edwin
Psaty, Bruce M.
Raitakari, Olli T.
Ralston, Stuart W.
Ridker, Paul M.
Robbins, John A.
Smith, Albert V.
Styrkarsdottir, Unnur
Tranah, Gregory J.
Thorstensdottir, Unnur
Uitterlinden, Andre G.
Zmuda, Joseph
Zillikens, M. Carola
Ntzani, Evangelia E.
Evangelou, Evangelos
Ioannidis, John P. A.
Evans, David M.
Ohlsson, Claes
Title Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2017-07-12
Sub-type Article (original research)
DOI 10.1038/ncomms16015
Open Access Status DOI
Volume 8
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 30 Jul 2017, 01:00:44 EST by System User on behalf of Learning and Research Services (UQ Library)