Mechanical properties and biocompatibility of porous titanium scaffolds for bone tissue engineering

Chen, Yunhui, Frith, Jessica Ellen, Dehghan-Manshadi, Ali, Attar, Hooyar, Kent, Damon, Soro, Nicolas Dominique Mathieu, Bermingham, Michael J. and Dargusch, Matthew S. (2017) Mechanical properties and biocompatibility of porous titanium scaffolds for bone tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials, 75 169-174. doi:10.1016/j.jmbbm.2017.07.015

Author Chen, Yunhui
Frith, Jessica Ellen
Dehghan-Manshadi, Ali
Attar, Hooyar
Kent, Damon
Soro, Nicolas Dominique Mathieu
Bermingham, Michael J.
Dargusch, Matthew S.
Title Mechanical properties and biocompatibility of porous titanium scaffolds for bone tissue engineering
Journal name Journal of the Mechanical Behavior of Biomedical Materials   Check publisher's open access policy
ISSN 1878-0180
Publication date 2017-07-07
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.jmbbm.2017.07.015
Open Access Status Not yet assessed
Volume 75
Start page 169
End page 174
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract Synthetic scaffolds are a highly promising new approach to replace both autografts and allografts to repair and remodel damaged bone tissue. Biocompatible porous titanium scaffold was manufactured through a powder metallurgy approach. Magnesium powder was used as space holder material which was compacted with titanium powder and removed during sintering. Evaluation of the porosity and mechanical properties showed a high level of compatibility with human cortical bone. Interconnectivity between pores is higher than 95% for porosity as low as 30%. The elastic moduli are 44.2 GPa, 24.7 GPa and 15.4 GPa for 30%, 40% and 50% porosity samples which match well to that of natural bone (4-30 GPa). The yield strengths for 30% and 40% porosity samples of 221.7 MPa and 117 MPa are superior to that of human cortical bone (130-180 MPa). In-vitro cell culture tests on the scaffold samples using Human Mesenchymal Stem Cells (hMSCs) demonstrated their biocompatibility and indicated osseointegration potential. The scaffolds allowed cells to adhere and spread both on the surface and inside the pore structures. With increasing levels of porosity/interconnectivity, improved cell proliferation is obtained within the pores. It is concluded that samples with 30% porosity exhibit the best biocompatibility. The results suggest that porous titanium scaffolds generated using this manufacturing route have excellent potential for hard tissue engineering applications.
Keyword Biocompatibility
Powder metallurgy
Space holder
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID IH150100024
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mechanical & Mining Engineering Publications
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Created: Fri, 28 Jul 2017, 14:02:05 EST by Yunhui Chen on behalf of Faculty Of Engineering, Architecture & Info Tech