Histological analysis of gallbladder diseases in relation to opisthorchiasis in endemic areas of Thailand

Sripa, B., Haswell-Elkins, M. R. and Sinawat, P. (2003) Histological analysis of gallbladder diseases in relation to opisthorchiasis in endemic areas of Thailand. Acta Tropica, 88 3: 239-246. doi:10.1016/j.actatropica.2003.09.007

Author Sripa, B.
Haswell-Elkins, M. R.
Sinawat, P.
Title Histological analysis of gallbladder diseases in relation to opisthorchiasis in endemic areas of Thailand
Journal name Acta Tropica   Check publisher's open access policy
ISSN 0001-706X
Publication date 2003-11-01
Sub-type Article (original research)
DOI 10.1016/j.actatropica.2003.09.007
Volume 88
Issue 3
Start page 239
End page 246
Total pages 8
Place of publication Netherlands
Publisher Elsevier
Language eng
Subject C1
321020 Pathology
730101 Infectious diseases
1103 Clinical Sciences
Abstract Chronic gallbladder disease frequently accompanies infection with the liver fluke, Opisthorchis viverrini, in Northeast Thailand. However, the pathology and pathogenesis of the gallbladder disease have not been described. Accordingly, gallbladder specimens from 187 consecutive patients who had undergone cholecystectomy at a referral hospital in an endemic area in Thailand were histologically characterized in relation to O. viverrini infection. The infection was assessed by the presence of parasite eggs in the bile and/or antibody response to the liver fluke. The average level of parasite-specific IgG was significantly higher in patients with Opisthorchis eggs in the bile than those without (P < 0.001). The main histopathologic features of the gallbladder included inflammation, mucosal atrophy/or hyperplasia, goblet cell metaplasia, mucous gland hyperplasia, Rokitansky-Aschoff sinus formation, dysplasia and fibrosis. The fibrosis was strongly associated with elevated levels of Opisthorchis-specific antibody (P < 0.001) but not with the presence of parasite eggs. Other pathologic features did not vary in frequency or severity with parasitological status. Our results show that severe fibrosis of the gallbladder is a more common histologic feature of cholecystitis among those with O. viverrini infection compared to those without infection. The close relationship between parasite-specific IgG and severe fibrosis suggests that specific immune response to the parasite play an important role in the pathogenesis of the fibrotic change. (C) 2003 Elsevier B.V. All rights reserved.
Keyword Parasitology
Tropical Medicine
Opisthorchis Viverrini
Antibody Response
North-east Thailand
Viverrini Infection
Hepatobiliary Disease
Liver Fluke
Praziquantel Treatment
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 12:45:17 EST