10 years of GWAS discovery: biology, function, and translation

Visscher, Peter M., Wray, Naomi R., Zhang, Qian, Sklar, Pamela, McCarthy, Mark I., Brown, Matthew A. and Yang, Jian (2017) 10 years of GWAS discovery: biology, function, and translation. American Journal of Human Genetics, 101 1: 5-22. doi:10.1016/j.ajhg.2017.06.005


Author Visscher, Peter M.
Wray, Naomi R.
Zhang, Qian
Sklar, Pamela
McCarthy, Mark I.
Brown, Matthew A.
Yang, Jian
Title 10 years of GWAS discovery: biology, function, and translation
Journal name American Journal of Human Genetics   Check publisher's open access policy
ISSN 0002-9297
1537-6605
Publication date 2017-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ajhg.2017.06.005
Open Access Status Not yet assessed
Volume 101
Issue 1
Start page 5
End page 22
Total pages 18
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.
Keyword Genome-wide association study
SNP
Obesity
Auto-immune disease
Schizophrenia
Heritability
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Institute for Molecular Bioscience - Publications
 
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