Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

Derks, Eske M., Vorstman, Jacob A. S., Ripke, Stephan, Kahn, Rene S., The Schizophrenia Psychiatric Genomic Consortium, Mowry, Bryan and Ophoff, Roel A. (2012) Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. PLoS One, 7 6: e37852.1-e37852.7. doi:10.1371/journal.pone.0037852


Author Derks, Eske M.
Vorstman, Jacob A. S.
Ripke, Stephan
Kahn, Rene S.
The Schizophrenia Psychiatric Genomic Consortium
Mowry, Bryan
Ophoff, Roel A.
Title Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-06-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0037852
Open Access Status DOI
Volume 7
Issue 6
Start page e37852.1
End page e37852.7
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p<0.0001). In the case-control sample, the five psychosis dimensions were found to be significantly associated with genetic risk scores; the correlations ranged between.15 and.27 (all p<.001). However, these correlations were not significant in schizophrenia cases or controls separately. While this study confirms the presence of a genetic risk for schizophrenia as categorical diagnostic trait, we did not find evidence for the genetic risk underlying quantitative schizophrenia symptom dimensions. This does not necessarily imply that a genetic basis is nonexistent, but does suggest that it is distinct from the polygenic risk score for schizophrenia.
Keyword Psychosis
Schizophrenia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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